Title:
神経変性疾患の処置に有用なウィザノライド
Document Type and Number:
Japanese Patent JP6517833
Kind Code:
B2
Abstract:
Provided herein are synthetic analogs of withanolide natural products of formula (I), wherein R1-R4 are as defined herein, and their pharmaceutical uses in treating neurodegenerative diseases.
Inventors:
Shaw, Anthony A.
Julien, Jean-Pierre
Chan, Agnes H.
Julien, Jean-Pierre
Chan, Agnes H.
Application Number:
JP2016554830A
Publication Date:
May 22, 2019
Filing Date:
November 25, 2014
Export Citation:
Assignee:
Imstar Therapeutics, Inc.
Unival City Laval
Unival City Laval
International Classes:
C07J71/00; A61K31/58; A61P21/00; A61P25/02; A61P25/16; A61P25/28
Foreign References:
| US20120196815 | ||||
| WO2010030395A1 | ||||
| WO2010053655A1 | ||||
| WO2012174666A1 |
Other References:
LLANOS GABRIEL G; ARAUJO LILIANA M; JIMENEZ IGNACIO A; MOUJIR LAILA M; BAZZOCCHI ISABEL L,WITHAFERIN A-RELATED STEROIDS FROMWITHANIA ARISTATAEXHIBIT POTENT ANTIPROLIFERATIVE 以下備考,EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY EDITIONS SCIENTIFIQUE,フランス,ELSEVIER,2012年,VOL:54,PAGE(S):499 - 511,ACTIVITY BY INDUCING APOPTOSIS IN HUMAN TUMOR CELLS,URL,http://dx.doi.org/10.1016/j.ejmech.2012.05.032
FUSKA J; PROUSEK J; ROSAZZA J; M B,MICROBIAL TRANSFORMATIONS OF NATURAL ANTITUMOR AGENTS. 23. CONVERSION OF WITHAFERIN-A TO 以下備考,STEROIDS,米国,ELSEVIER SCIENCE PUBLISHERS,1982年 8月 1日,VOL:40, NR:2,PAGE(S):157 - 169,12BETA- AND 15BETA-HYDROXY DERIVATIVES OF WITHAFERIN-A,URL,http://dx.doi.org/10.1016/0039-128X(82)90030-7
YOKOTA YASUNO; BARGAGNA-MOHAN PAOLA; RAVINDRANATH PADMA P; KIM KYUNG B; MOHAN ROYCE,DEVELOPMENT OF WITHAFERIN A ANALOGS AS PROBES OF ANGIOGENESIS,BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,NL,PERGAMON,2006年,VOL:16, NR:10,PAGE(S):2603 - 2607,URL,http://dx.doi.org/10.1016/j.bmcl.2006.02.039
FUSKA J; PROUSEK J; ROSAZZA J; M B,MICROBIAL TRANSFORMATIONS OF NATURAL ANTITUMOR AGENTS. 23. CONVERSION OF WITHAFERIN-A TO 以下備考,STEROIDS,米国,ELSEVIER SCIENCE PUBLISHERS,1982年 8月 1日,VOL:40, NR:2,PAGE(S):157 - 169,12BETA- AND 15BETA-HYDROXY DERIVATIVES OF WITHAFERIN-A,URL,http://dx.doi.org/10.1016/0039-128X(82)90030-7
YOKOTA YASUNO; BARGAGNA-MOHAN PAOLA; RAVINDRANATH PADMA P; KIM KYUNG B; MOHAN ROYCE,DEVELOPMENT OF WITHAFERIN A ANALOGS AS PROBES OF ANGIOGENESIS,BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,NL,PERGAMON,2006年,VOL:16, NR:10,PAGE(S):2603 - 2607,URL,http://dx.doi.org/10.1016/j.bmcl.2006.02.039
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto