To solve a problem of need to elucidate the further members of the families, including cell-surface molecules that may be tumor-specific antigens or proteins that serve a regulatory function in initiating the Wnt pathway of tumorigenesis and also including downstream components of the Wnt signaling pathway that are important to a transformed phenotype and the development of cancer.
Wnt-1-Induced Secreted Proteins (WISPs) are provided, whose genes are induced at least by Wnt-1. Also provided are nucleic acid molecules encoding those polypeptides, as well as vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides, and methods for producing the polypeptides.
COHEN ROBERT L
GURNEY AUSTIN L
HILLAN KENNETH
LAWRENCE DAVID A
LEVINE ARNOLD J
DIAN PENNICA
ROY MARGARET ANN
GODDARD AUDREY
WOOD WILLIAM I
| JP2001504336A | 2001-04-03 |
| WO1998021236A1 | 1998-05-22 |
Takashi Watanabe
Yasuhiko Murayama
Shinya Mitsuhiro