WRINKLE SUPPRESSIVE PREPARATION FOR EXTERNAL USE FOR SKIN

Title:

WRINKLE SUPPRESSIVE PREPARATION FOR EXTERNAL USE FOR SKIN

Document Type and Number:

Japanese Patent JPH10291929

Kind Code:

A

Abstract:

To obtain the subject preparation for external use useful for cosmetics and medicines by formulating rosmarinic acid thereto.

The rosmarinic acid-containing extract is obtained by immersing (a) terrestrial parts of labiate plants (preferably sage, rosemary, beefsteak plant, thyme or Isdon japonicus Hara) of raw material in (b) water and a lower alcohol (methyl alcohol and the like) in a/b (w/v) ratio of 1/500-1/2, preferably 1/50-1/5, at usually 5-100°C for 1-4 hrs., if necessary under stirring and/or heating. The extract is, if necessary, further purified and then added to a preparation for external use for skin in an amount of 0.0001-2 wt.%, preferably 0.001-10 wt.% to give the subject high safe preparation for external use which inhibits collagenase and collagene crosslink polymerization.

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Inventors:

MIYAZAKI TOSHITSUGU
ITO HISATOMI
KOSAKA KUNIO

Application Number:

JP10311197A

Publication Date:

November 04, 1998

Filing Date:

April 21, 1997

Export Citation:

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Assignee:

NAGASE & CO LTD

International Classes:

A61K8/30; A61K8/00; A61K8/33; A61K8/96; A61K8/97; A61K31/19; A61K36/53; A61P17/00; A61P43/00; A61Q19/00; (IPC1-7): A61K31/19; A61K7/00; A61K7/48; A61K35/78

Domestic Patent References:

JPH0967251A	1997-03-11
JPS63162611A	1988-07-06
JPH09136824A	1997-05-27
JPH0625000A	1994-02-01
JPH07196526A	1995-08-01

Attorney, Agent or Firm:

Aoyama Ryo (1 person outside)

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