Title:
新規の種類のヒストン脱アセチル化酵素阻害剤としてのＺｎ２＋キレートモチーフ係留短鎖脂肪酸
Document Type and Number:
Japanese Patent JP5702681
Kind Code:
B2
Abstract:
Zn2+-chelating motif-tethered fatty acids as histone deacetylase (HDAC) inhibitors. Compounds performed well in in vitro and in vivo tests.
Inventors:
Chin-Chi Chen
Cian Lou
Cian Lou
Application Number:
JP2011144993A
Publication Date:
April 15, 2015
Filing Date:
June 29, 2011
Export Citation:
Assignee:
The Ohio State University Research Foundation
International Classes:
C07C237/20; A61K31/167; A61K31/19; A61K31/4402; C07C237/22; C07C237/40; C07C237/42; C07C259/06; C07C259/10; C07D213/81; A61K
Domestic Patent References:
| JP5107573B2 | ||||
| JP2004509941A | ||||
| JP11302173A | ||||
| JP2003137866A | ||||
| JP63115852A | ||||
| JP10152462A | ||||
| JP2006509021A | ||||
| JP56068650A | ||||
| JP2007503430A |
Foreign References:
| WO2002026696A1 | ||||
| WO2004052838A1 | ||||
| WO2003070691A1 | ||||
| US20020172967 | ||||
| WO2005019162A1 |
Other References:
KRAKER, AJ. et al,Molecular Cancer Therapeutics,2003年 4月,Vol.2,p.401-408
KIM,DK. et al,J Med Chem,2003年 1月,Vol.46,p.5745-5751
KIM,DK. et al,J Med Chem,2003年 1月,Vol.46,p.5745-5751
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita