Title:
【発明の名称】トラマドールのシストランスジアステレオマーの分離法
Document Type and Number:
Japanese Patent JP2003531881
Kind Code:
A
Abstract:
A process for separating a mixture of trans (RR, SS) and cis (RS, SR) tramadol comprises a classical salt resolution using a chiral resolving agent selected from tartaric acid and derivatives thereof, and mandelic acid, provided that the resolving agent is not substantially single enantiomer di-O,O-toluoyltartaric acid.
Inventors:
Graham Evans
Application Number:
JP2001580853A
Publication Date:
October 28, 2003
Filing Date:
March 19, 2001
Export Citation:
Assignee:
DARWIN DISCOVERY LIMITED
International Classes:
C07B57/00; C07C213/10; C07C217/74; (IPC1-7): C07C213/10; C07C217/74
Attorney, Agent or Firm:
Kaoru Aoyama (3 people outside)