An albumin nanoparticle constituent by which the lipid coat was carried out, the method of producing it, and the method of using it

Japanese Patent JP6228191

B2

Described is a lipid nanoparticle composition that includes a macromolecule conjugated to a polymer and a targeting agent. The composition can include a therapeutic agent. The therapeutic agent can be an antisense oligonucleotide (ASO). Exemplary ASOs are targeted to a portion of a nucleic acid encoding Akt-1, and which modulates the expression of Akt-1; or targeted to a portion of a nucleic acid encoding HIF-1, and which modulates the expression of HIF-1. Also described is a lipid nanoparticle composition that includes a macromolecule conjugated to a polymer and a therapeutic agent that is an ASO such as an ASO targeted to a portion of a nucleic acid encoding Akt-1, and which modulates the expression of Akt-1 or an ASO targeted to a portion of a nucleic acid encoding HIF-1, and which modulates the expression of HIF-1. Pharmaceutical formulations, methods of making the lipid nanoparticles, and methods of using the lipid nanoparticles, for example for treating cancers, are also disclosed.

Lee, Robert Jay

JP2015514193A

November 08, 2017

May 23, 2013

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The Ohio State University

A61K47/42; A61K9/51; A61K31/711; A61K38/08; A61K47/18; A61K47/22; A61K47/24; A61K47/34; B82Y5/00; B82Y30/00

JP2006298780A

US6821955
US20110319473
US0590877

CYTOKINE,2005年,Vol.29,p.283-287
Biomaterials,2010年,Vol.31,p.952-963
Journal of Controlled Release,2003年,Vol.92,p.199-208
Biomaterials,2009年,Vol.30,p.5143-5155
Cell Biochem. Biophys.,2011年,Vol.61,p.277-287

Shinjiro Ono
Yasushi Kobayashi
Shigeo Takeuchi
Osamu Yamamoto
Hirose Shinobu
Err

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