Title:
疾患治療用アルコキシ化合物
Document Type and Number:
Japanese Patent JP2011512321
Kind Code:
A
Abstract:
The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are alkoxyl derivative compounds and pharmaceutical compositions comprising these compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.
Inventors:
Scott, Ian, Elle.
Kukusa, Vladimir, ray.
Olme, Mark, W.
Little, thomas
Gall, Anna
Hung, Feng
Kukusa, Vladimir, ray.
Olme, Mark, W.
Little, thomas
Gall, Anna
Hung, Feng
Application Number:
JP2010527992A
Publication Date:
April 21, 2011
Filing Date:
October 03, 2008
Export Citation:
Assignee:
Accucera, Inc.
International Classes:
C07C217/62; A61K31/137; A61K31/138; A61K31/155; A61K31/164; A61K31/351; A61K31/426; A61P27/02; C07C217/20; C07C217/72; C07C225/16; C07C229/38; C07C233/18; C07C235/06; C07C235/08; C07C257/14; C07C257/22; C07C279/08; C07C317/32; C07C323/32; C07D277/24; C07D309/06
Domestic Patent References:
| JPH08176080A | 1996-07-09 | |||
| JP2001525796A | 2001-12-11 | |||
| JPH0741468A | 1995-02-10 | |||
| JPS50112386A | 1975-09-03 | |||
| JPH11503418A | 1999-03-26 |
Foreign References:
| WO2007038372A1 | 2007-04-05 | |||
| WO1993015045A1 | 1993-08-05 | |||
| WO2005020882A2 | 2005-03-10 | |||
| WO2006113837A2 | 2006-10-26 | |||
| US3987158A | 1976-10-19 | |||
| WO2007079593A1 | 2007-07-19 |
Other References:
JPN6013043970; 船久保 英一、外２名: '樟脳副産油の利用研究（第二十三報） beta-メチルアドレナリンの合成（ＩＩＩ）' 日本化学會誌 Ｖｏｌ．６３, 1942, ｐ．１６５２-１６５６
JPN6013043969; ＥＰＳＴＥＩＮ，Ｅ．: 'Ａｌｋｏｘｙｐｈｅｎｙｌ Ｎ-ｓｕｂｓｔｉｔｕｔｅｄ ａｍｉｎｏｐｒｏｐａｎｏｌｓ' Ｊｏｕｒｎａｌ ｏｆ ｔｈｅ Ａｍｅｒｉｃａｎ Ｃｈｅｍｉｃａｌ Ｓｏｃｉｅｔｙ Ｖｏｌ．８１, 1959, ｐ．６２０７-６２０９
JPN6014034538; ＫＵＣＫＬＡＥＮＤＥＲ，Ｕ． ｅｔ ａｌ．: 'Ｉｎｖｅｓｔｉｇａｔｉｏｎｓ ｏｎ ｔｈｅ ｆｏｒｍａｔｉｏｎ ｏｆ ６-ｈｙｄｒｏｘｙｉｎｄｏｌｅ ｉｎ ｔｈｅ ｎｅｎｉｔｚｅｓｃｕ ｒｅａｃｔｉｏｎ． ＩＩ． Ｃｙｃｌｉｚａｔｉｏｎ ｏｆ Ｎ-' Ｃｈｅｍｉｓｃｈｅ Ｂｅｒｉｃｈｔｅ Ｖｏｌ．１２２， Ｎｏ．８, 1989, ｐ．１４９３-１４９８
JPN6014034539; ＫＡＮＯ，Ｓ． ｅｔ ａｌ．: 'Ｆｏｒｍａｔｉｏｎ ｏｆ ｄｉｂｅｎｚｏ［ｂ，ｆ］ａｚｅｃｉｎｅｓ ｂｙ ｔｈｅ ｒｅａｃｔｉｏｎ ｏｆ １-ｈａｌｏｇｅｎｏ-ｐｈｅｎｅｔｈｙｌ-１Ｈ-２-ｂｅｎｚａｚｅｐｉｎｅｓ ｗｉｔｈ ｄｉｍ' Ｃｈｅｍｉｃａｌ ＆ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｂｕｌｌｅｔｉｎ Ｖｏｌ．２５， Ｎｏ．１１, 1977, ｐ．２８７５-２８８１
JPN6014034540; ＷＩＴＴＩＧ，Ｔ．Ｗ． ｅｔ ａｌ．: 'Ｄｏｐａｍｉｎｅ／Ｓｅｒｏｔｏｎｉｎ Ｒｅｃｅｐｔｏｒ Ｌｉｇａｎｄｓ． ９．１ Ｏｘｙｇｅｎ-Ｃｏｎｔａｉｎｉｎｇ Ｍｉｄｓｉｚｅｄ Ｈｅｔｅｒｏｃｙｃｌｉｃ Ｒｉｎｇ Ｓｙｓｔｅｍｓ ａｎｄ Ｎｏ' Ｊｏｕｒｎａｌ ｏｆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．４７, 2004, ｐ．４１５５-８、Ｓｕｐｐｏｒｔｉｎｇ Ｉｎｆｏｒｍａｔｉｏｎ ｐ．Ｓ１-Ｓ８
JPN6013043969; ＥＰＳＴＥＩＮ，Ｅ．: 'Ａｌｋｏｘｙｐｈｅｎｙｌ Ｎ-ｓｕｂｓｔｉｔｕｔｅｄ ａｍｉｎｏｐｒｏｐａｎｏｌｓ' Ｊｏｕｒｎａｌ ｏｆ ｔｈｅ Ａｍｅｒｉｃａｎ Ｃｈｅｍｉｃａｌ Ｓｏｃｉｅｔｙ Ｖｏｌ．８１, 1959, ｐ．６２０７-６２０９
JPN6014034538; ＫＵＣＫＬＡＥＮＤＥＲ，Ｕ． ｅｔ ａｌ．: 'Ｉｎｖｅｓｔｉｇａｔｉｏｎｓ ｏｎ ｔｈｅ ｆｏｒｍａｔｉｏｎ ｏｆ ６-ｈｙｄｒｏｘｙｉｎｄｏｌｅ ｉｎ ｔｈｅ ｎｅｎｉｔｚｅｓｃｕ ｒｅａｃｔｉｏｎ． ＩＩ． Ｃｙｃｌｉｚａｔｉｏｎ ｏｆ Ｎ-' Ｃｈｅｍｉｓｃｈｅ Ｂｅｒｉｃｈｔｅ Ｖｏｌ．１２２， Ｎｏ．８, 1989, ｐ．１４９３-１４９８
JPN6014034539; ＫＡＮＯ，Ｓ． ｅｔ ａｌ．: 'Ｆｏｒｍａｔｉｏｎ ｏｆ ｄｉｂｅｎｚｏ［ｂ，ｆ］ａｚｅｃｉｎｅｓ ｂｙ ｔｈｅ ｒｅａｃｔｉｏｎ ｏｆ １-ｈａｌｏｇｅｎｏ-ｐｈｅｎｅｔｈｙｌ-１Ｈ-２-ｂｅｎｚａｚｅｐｉｎｅｓ ｗｉｔｈ ｄｉｍ' Ｃｈｅｍｉｃａｌ ＆ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｂｕｌｌｅｔｉｎ Ｖｏｌ．２５， Ｎｏ．１１, 1977, ｐ．２８７５-２８８１
JPN6014034540; ＷＩＴＴＩＧ，Ｔ．Ｗ． ｅｔ ａｌ．: 'Ｄｏｐａｍｉｎｅ／Ｓｅｒｏｔｏｎｉｎ Ｒｅｃｅｐｔｏｒ Ｌｉｇａｎｄｓ． ９．１ Ｏｘｙｇｅｎ-Ｃｏｎｔａｉｎｉｎｇ Ｍｉｄｓｉｚｅｄ Ｈｅｔｅｒｏｃｙｃｌｉｃ Ｒｉｎｇ Ｓｙｓｔｅｍｓ ａｎｄ Ｎｏ' Ｊｏｕｒｎａｌ ｏｆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．４７, 2004, ｐ．４１５５-８、Ｓｕｐｐｏｒｔｉｎｇ Ｉｎｆｏｒｍａｔｉｏｎ ｐ．Ｓ１-Ｓ８
Attorney, Agent or Firm:
Asamura patent office
Hideto Asamura
Hajime Asamura
Yuko Nagase
Naganuma Akio
Yukihiro Ikeda
Kajiwara Saiko
Shinmura Morio
Kanamori Koji
Youichi Inoue
Mari Yuge
Yoshitaka Watanabe
Hideto Asamura
Hajime Asamura
Yuko Nagase
Naganuma Akio
Yukihiro Ikeda
Kajiwara Saiko
Shinmura Morio
Kanamori Koji
Youichi Inoue
Mari Yuge
Yoshitaka Watanabe