(アルファS,ベータR)-6-ブロモ-アルファ-[2-(ジメチルアミノ)エチル]-2-メトキシ-アルファ-1-ナフタレニル-ベータ-フェニル-3-キノリンエタノールの製造方法 - JANSSEN PHARMACEUTICA NAAMLOZE VENNOOTSCHAP

Title:

(アルファS,ベータR)-6-ブロモ-アルファ-[2-(ジメチルアミノ)エチル]-2-メトキシ-アルファ-1-ナフタレニル-ベータ-フェニル-3-キノリンエタノールの製造方法

Document Type and Number:

Japanese Patent JP5410749

Kind Code:

B2

Abstract:

The present invention relates to a process for isolating (αS,βR)-6-bromo-α-[2-(dimethylamino)ethyl]-2-methoxy-α-1-naphthalenyl-β-phenyl-3-quinolineethanol from a mixture of stereoisomeric forms of 6-bromo-α-[2-(dimethylamino)ethyl]-2-methoxy-α-1-naphthalenyl-β-phenyl-3-quinolineethanol by optical resolution with chiral 4-hydroxydinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin 4-oxide or a derivative thereof, in particular (11bR)-4-hydroxydinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin 4-oxide, as resolution agent.

More Like This:

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Inventors:

Frank Ralph, Portsman
Horns, Siute Juan
Thomas Badell

Application Number:

JP2008512822A

Publication Date:

February 05, 2014

Filing Date:

May 22, 2006

Export Citation:

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Assignee:

JANSSEN PHARMACEUTICA NAAMLOZE VENNOOTSCHAP

International Classes:

C07D215/22; C07B57/00; C07F9/6574

Domestic Patent References:

JP6234711A

Foreign References:

WO2004011436A1
WO2004060889A1

Other References:

Tetrahedron Letters,1971年,Vol.48,p.4617-4620
Journal of Medicinal Chemistry ,1984年,Vol.27,p.165-175
Journal of the Chemical Society, Perkin Transaction 2,1994年,Vol.8,p.1731-1733

Attorney, Agent or Firm:

Patent business corporation Odashima patent office

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