Title:
アミド誘導体またはその塩
Document Type and Number:
Japanese Patent JP5157892
Kind Code:
B2
Abstract:
[Problem] To provide a compound which can be used for the prevention and/or treatment of diseases in which 5-HT 2B receptor and 5-HT 7 receptor are concerned, particularly for the treatment of irritable bowel syndrome (IBS). [Means for Resolution] It was found that an amide derivative characterized by the possession of a nitrogen-containing bicyclic hetero ring (e.g., an indole or the like), or a pharmaceutically acceptable salt thereof, has a strong antagonism for both of the 5-HT 2B receptor and 5-HT 7 receptor. In addition, the compound of the present invention having the antagonistic activity for both of the receptors showed a good pharmacological action in comparison with the case in which an antagonist selective for either one of the receptors was used alone. Based on the above, the compound of the present invention is useful for the prevention and/or treatment of diseases in which 5-HT 2B receptor and 5-HT 7 receptor are concerned, particularly for the treatment of irritable bowel syndrome (IBS).
Inventors:
Hideki Karai
Hiromi Yamada
Daisuke Kaga
Ryushi Seo
Shinobu Akuzawa
Hiromi Yamada
Daisuke Kaga
Ryushi Seo
Shinobu Akuzawa
Application Number:
JP2008501670A
Publication Date:
March 06, 2013
Filing Date:
February 07, 2007
Export Citation:
Assignee:
Astellas Pharma Inc.
International Classes:
C07D209/08; A61K31/404; A61K31/4184; A61K31/422; A61K31/423; A61K31/4245; A61K31/428; A61K31/433; A61K31/439; A61K31/4439; A61K31/454; A61K31/47; A61K31/4709; A61K31/496; A61K31/4985; A61K31/4995; A61K31/5377; A61K31/538; A61K31/55; A61K31/551; A61P1/04; A61P43/00; C07D209/12; C07D209/14; C07D209/30; C07D215/48; C07D235/06; C07D235/08; C07D235/10; C07D235/26; C07D265/36; C07D401/06; C07D401/12; C07D401/14; C07D403/06; C07D403/10; C07D403/12; C07D403/14; C07D405/04; C07D405/06; C07D405/12; C07D409/06; C07D409/12; C07D413/06; C07D413/12; C07D417/06; C07D453/02; C07D471/04; C07D487/04; C07D487/08
Domestic Patent References:
| JPH0848671A | 1996-02-20 | |||
| JP2005162657A | 2005-06-23 | |||
| JPH0710839A | 1995-01-13 | |||
| JPH0848671A | 1996-02-20 |
Foreign References:
| EP0639573A1 | 1995-02-22 |
Other References:
JPN6012046841; ＶＯＵＲＬＯＵＭＩＳ，Ｄ． ｅｔ ａｌ．: 'Ｓｏｌｉｄ-ｐｈａｓｅ ｓｙｎｔｈｅｓｉｓ ｏｆ ｂｅｎｚｉｍｉｄａｚｏｌｅ ｌｉｂｒａｒｉｅｓ ｂｉａｓｅｄ ｆｏｒ ＲＮＡ ｔａｒｇｅｔｓ' Ｔｅｔｒａｈｅｄｒｏｎ Ｌｅｔｔｅｒｓ Ｖｏｌ．４４， Ｎｏ．１４, 2003, ｐ．２８０７-２８１１
JPN6012046841; ＶＯＵＲＬＯＵＭＩＳ，Ｄ． ｅｔ ａｌ．: 'Ｓｏｌｉｄ-ｐｈａｓｅ ｓｙｎｔｈｅｓｉｓ ｏｆ ｂｅｎｚｉｍｉｄａｚｏｌｅ ｌｉｂｒａｒｉｅｓ ｂｉａｓｅｄ ｆｏｒ ＲＮＡ ｔａｒｇｅｔｓ' Ｔｅｔｒａｈｅｄｒｏｎ Ｌｅｔｔｅｒｓ Ｖｏｌ．４４， Ｎｏ．１４, 2003, ｐ．２８０７-２８１１
JPN6012046841; ＶＯＵＲＬＯＵＭＩＳ，Ｄ． ｅｔ ａｌ．: 'Ｓｏｌｉｄ-ｐｈａｓｅ ｓｙｎｔｈｅｓｉｓ ｏｆ ｂｅｎｚｉｍｉｄａｚｏｌｅ ｌｉｂｒａｒｉｅｓ ｂｉａｓｅｄ ｆｏｒ ＲＮＡ ｔａｒｇｅｔｓ' Ｔｅｔｒａｈｅｄｒｏｎ Ｌｅｔｔｅｒｓ Ｖｏｌ．４４， Ｎｏ．１４, 2003, ｐ．２８０７-２８１１
Attorney, Agent or Firm:
Morita Taku
Emiko Yano
鈴木 ▲頼▼子
Hamai Kosuke
Emiko Yano
鈴木 ▲頼▼子
Hamai Kosuke