amino alcohol lipid -- an id and its use - MASSACHUSETTS INSTITUTE OF TECHNOLOGY

Title:

amino alcohol lipid -- an id and its use

Document Type and Number:

Japanese Patent JP6087504

Kind Code:

B2

Abstract:

Aminoalcohol lipidoids are prepared by reacting an amine with an epoxide-terminated compound are described. Methods of preparing aminoalcohol lipidoids from commercially available starting materials are also provided. Aminoalcohol lipidoids may be prepared from racemic or stereochemically pure epoxides. Aminoalcohol lipidoids or salts forms thereof are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the amino moiety of these aminoalcohol lipidoid compounds, they are particularly suited for the delivery of polynucleotides. Complexes, micelles, liposomes or particles containing the inventive lipidoids and polynucleotide have been prepared. The inventive lipidoids may also be used in preparing microparticles for drug delivery. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.

More Like This:

JP5890315	Amino alcohol compounds, precursors, and preparation methods and uses
WO/2021/236771	METHODS AND COMPOSITIONS FOR TARGETING PD-L1

Inventors:

Marne, kelly, peter
Love, Kevin, Thomas
Levins, Christopher, Gee.
Whitehead, Kathryn, Anne
Langer, Robert, Es.
Anderson, Daniel, Griffith

Application Number:

JP2011535564A

Publication Date:

March 01, 2017

Filing Date:

November 06, 2009

Export Citation:

Click for automatic bibliography generation Help

Assignee:

MASSACHUSETTS INSTITUTE OF TECHNOLOGY

International Classes:

C07C215/14; A61K9/127; A61K9/14; A61K31/7088; A61K38/00; A61K45/00; A61K47/18; A61K47/22; A61K47/28; A61K47/34; C07B57/00; C07B61/00; C07C213/04; C07C217/08; C07D203/12; C07D209/14; C07D211/58; C07D213/36; C07D213/74; C07D231/12; C07D241/20; C07D295/12; C07D307/14; C07D307/20; C07D307/52; C07D317/72

Domestic Patent References:

JP2003519199A
JP5210847B1
JP49127908A
JP5123537A
JP6211978A
JP6200073A

Foreign References:

US3956502

Other References:

Aravind Asokan 外1名,Bioconjugate Chemistry,2004年,Vol.15,No.6,1166-1173
L.Conte 外6名,Journal of Fluorine Chemistry,2005年,Vol.126,1276-1280
Naoya Ichimaru 外8名,Biochemistry,2008,47,10816-10826

Attorney, Agent or Firm:

Kiyoji Kuzuwa

Previous Patent: Human anti-PD-1, PD-L1 and PD-L2 antibody, and its use

Next Patent: JPS6087505