Title:
【発明の名称】抗血栓剤または抗凝固剤としてのアミノヘテロ環状誘導体
Document Type and Number:
Japanese Patent JP2000504337
Kind Code:
A
Abstract:
Compounds of formula (I), wherein G1 is CH or N; G2 is CH or N; R1 is a variety of optional substituents; L1 is (1-4C)alkylene; T1 is CH or N; R2 and R3 are independently hydrogen or (1-4C)alkyl or are joined to form a ring; X1 and X2 represent various linking groups; Ar is phenylene or certain heteroaryl rings and Q represents a variety of aromatic or heterocyclic rings systems, and pharmaceutically acceptable salts thereof are described as useful antithrombotic and anticoagulant agents, and are selective Factor Xa inhibitors. Processes for their preparation and pharmaceutical compositions containing them are also described.
Inventors:
Smithers, Michael James
Preston, John
Stocker, Andrew
Preston, John
Stocker, Andrew
Application Number:
JP52742897A
Publication Date:
April 11, 2000
Filing Date:
January 31, 1997
Export Citation:
Assignee:
Geneca Limited
International Classes:
A61K31/00; A61K31/44; A61K31/4427; A61K31/4439; A61K31/445; A61K31/4465; A61K31/4523; A61K31/4545; A61K31/47; A61K31/472; A61K31/4725; A61K31/495; A61K31/496; A61K31/50; A61K31/505; A61K31/506; A61K31/55; A61K31/551; A61K31/5513; A61P7/00; A61P7/02; A61P9/00; A61P9/10; A61P25/00; C07D213/74; C07D237/20; C07D239/42; C07D401/04; C07D401/12; C07D401/14; H04R1/42; H04R7/06; H04R23/02; (IPC1-7): C07D213/74; A61P7/02; A61P9/10; A61P25/00; A61K31/4439; A61K31/4545; A61K31/4725; A61K31/496; A61K31/506; A61K31/5513; C07D239/42; C07D401/04; C07D401/12; C07D401/14
Attorney, Agent or Firm:
Shusaku Yamamoto