The antigen joint molecule repeatedly combined with a child's antigen for two or more minutes

Title:

The antigen joint molecule repeatedly combined with a child's antigen for two or more minutes

Document Type and Number:

Japanese Patent JP6030452

Kind Code:

B2

Abstract:

An objective of the present invention is to provide methods for promoting antigen uptake into cells by antigen-binding molecules, methods for increasing the number of times of antigen binding by one antigen-binding molecule, methods for promoting reduction of the antigen concentration in plasma by administering antigen-binding molecules, and methods for improving the plasma retention of an antigen-binding molecule, as well as antigen-binding molecules that allow enhanced antigen uptake into cells, antigen-binding molecules having an increased number of times of antigen binding, antigen-binding molecules that can promote reduction of the antigen concentration in plasma when administered, antigen-binding molecules with improved plasma retention, pharmaceutical compositions comprising the above antigen-binding molecules, and methods for producing them. The present inventors revealed that the above objective can be achieved by using antigen-binding molecules that show calcium-dependent antigen-antibody reaction.

Inventors:

Tomoyuki Ikawa
Shinya Ishii
Miho Funaki
Hiroba Naoka
Atsuhiko Maeda
Junichi Nezu
Keike Naoto
Baba Takeshi
Shimizu Hayao

Application Number:

JP2012546907A

Publication Date:

November 24, 2016

Filing Date:

November 30, 2011

Export Citation:

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Assignee:

Chugai Pharmaceutical Co., Ltd.

International Classes:

C12N15/09; A61K39/395; C07K16/18; C07K16/46; C12P21/08

Domestic Patent References:

JPS61117457A	1986-06-04
JPH02163085A	1990-06-22
JPS6352890A	1988-03-07
JPS61117457A	1986-06-04

Foreign References:

WO2009041062A1	2009-04-02
WO2009125825A1	2009-10-15
WO2009041062A1	2009-04-02
WO2009125825A1	2009-10-15

Other References:

JPN6012026890; ＹＥＵＮＧ，　Ｙ．Ａ．　ｅｔ　ａｌ．: '"Ｅｎｇｉｎｅｅｒｉｎｇ　ｈｕｍａｎ　ＩｇＧ１　ａｆｆｉｎｉｔｙ　ｔｏ　ｈｕｍａｎ　ｎｅｏｎａｔａｌ　Ｆｃ　ｒｅｃｅｐｔｏｒ：　ｉｍｐａｃｔ　ｏｆ　ａｆｆｉｎｉｔｙ　ｉｍｐｒｏｖｅｍｅｎｔ　ｏｎ　ｐｈ' Ｊ．　ＩＭＭＵＮＯＬ．Ｖｏｌ．１８２，　Ｎｏ．１１, 20090615, Ｐ．７６６３-７６７１
JPN6012026891; ＤＡＬＬ'ＡＣＱＵＡ，　Ｗ．Ｆ．　ｅｔ　ａｌ．: '"Ｉｎｃｒｅａｓｉｎｇ　ｔｈｅ　ａｆｆｉｎｉｔｙ　ｏｆ　ａ　ｈｕｍａｎ　ＩｇＧ１　ｆｏｒ　ｔｈｅ　ｎｅｏｎａｔａｌ　Ｆｃ　ｒｅｃｅｐｔｏｒ：　ｂｉｏｌｏｇｉｃａｌ　ｃｏｎｓｅｑｕｅｎｃｅｓ．"' Ｊ．　ＩＭＭＵＮＯＬ．Ｖｏｌ．１６９，　Ｎｏ．９, 20021101, Ｐ．５１７１-５１８０
JPN6015043121; ＳＴＥＡＲＮＳ，　Ｄ．Ｊ．　ｅｔ　ａｌ．: '"Ｔｈｅ　ｉｎｔｅｒａｃｔｉｏｎ　ｏｆ　ａ　Ｃａ２＋-ｄｅｐｅｎｄｅｎｔ　ｍｏｎｏｃｌｏｎａｌ　ａｎｔｉｂｏｄｙ　ｗｉｔｈ　ｔｈｅ　ｐｒｏｔｅｉｎ　Ｃ　ａｃｔｉｖａｔｉｏｎ　ｐｅｐｔｉｄｅ　ｒｅｇｉｏ' Ｊ．　ＢＩＯＬ．　ＣＨＥＭ．Ｖｏｌ．２６３，　Ｎｏ．２, 19880115, Ｐ．８２６-８３２
JPN6015043125; ＷＡＲＤ，　Ｓ．Ｌ．　ｅｔ　ａｌ．: '"Ａ　ｃａｌｃｉｕｍ-ｂｉｎｄｉｎｇ　ｍｏｎｏｃｌｏｎａｌ　ａｎｔｉｂｏｄｙ　ｔｈａｔ　ｒｅｃｏｇｎｉｚｅｓ　ａ　ｎｏｎ-ｃａｌｃｉｕｍ-ｂｉｎｄｉｎｇ　ｅｐｉｔｏｐｅ　ｉｎ　ｔｈｅ　ｓｈｏｒｔ　ｃｏ' ＭＯＬ．　ＩＭＭＵＮＯＬ．Ｖｏｌ．２９，　Ｎｏ．１, 199201, Ｐ．８３-９３
JPN6012026890; ＹＥＵＮＧ，　Ｙ．Ａ．　ｅｔ　ａｌ．: '"Ｅｎｇｉｎｅｅｒｉｎｇ　ｈｕｍａｎ　ＩｇＧ１　ａｆｆｉｎｉｔｙ　ｔｏ　ｈｕｍａｎ　ｎｅｏｎａｔａｌ　Ｆｃ　ｒｅｃｅｐｔｏｒ：　ｉｍｐａｃｔ　ｏｆ　ａｆｆｉｎｉｔｙ　ｉｍｐｒｏｖｅｍｅｎｔ　ｏｎ　ｐｈ' Ｊ．　ＩＭＭＵＮＯＬ．Ｖｏｌ．１８２，　Ｎｏ．１１, 20090615, Ｐ．７６６３-７６７１
JPN6012026891; ＤＡＬＬ'ＡＣＱＵＡ，　Ｗ．Ｆ．　ｅｔ　ａｌ．: '"Ｉｎｃｒｅａｓｉｎｇ　ｔｈｅ　ａｆｆｉｎｉｔｙ　ｏｆ　ａ　ｈｕｍａｎ　ＩｇＧ１　ｆｏｒ　ｔｈｅ　ｎｅｏｎａｔａｌ　Ｆｃ　ｒｅｃｅｐｔｏｒ：　ｂｉｏｌｏｇｉｃａｌ　ｃｏｎｓｅｑｕｅｎｃｅｓ．"' Ｊ．　ＩＭＭＵＮＯＬ．Ｖｏｌ．１６９，　Ｎｏ．９, 20021101, Ｐ．５１７１-５１８０

Attorney, Agent or Firm:

Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto

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