Title:
抗腫瘍化合物及びその医薬組成物
Document Type and Number:
Japanese Patent JP5117377
Kind Code:
B2
Abstract:
Chemical compounds identified by in silico molecular modelling, and having an structure that allows the blocking of the phosphorylation event, through the interaction of such compounds with the phosphorylation domain or its milieu in the substrates of the Casein Kinase 2 enzyme. This invention comprises also the pharmaceutical compositions containing such compounds, and their use in the preparation of medicines for the treatment of diseases related with neoplasic processes.
Inventors:
Rodriguez Fernandez, Roland, Eduardo
Bella Alvarez, Roberto
De La Nues Beurens, Ania
Mazola Reyes, Juliet
Perea Rodriguez, Silvio, Ernesto
Acebedo Castro, Boris, Ernesto
Musaccio Lhasa, Alexis
Ubieta Gomez, Raimund
Bella Alvarez, Roberto
De La Nues Beurens, Ania
Mazola Reyes, Juliet
Perea Rodriguez, Silvio, Ernesto
Acebedo Castro, Boris, Ernesto
Musaccio Lhasa, Alexis
Ubieta Gomez, Raimund
Application Number:
JP2008510389A
Publication Date:
January 16, 2013
Filing Date:
May 05, 2006
Export Citation:
Assignee:
Centro in the Any Area Energy Biotechnology
International Classes:
C07C211/14; A61K31/132; A61K31/16; A61K31/165; A61K31/175; A61K31/18; A61K31/197; A61K31/198; A61K31/275; A61K31/277; A61K31/341; A61K31/40; A61K31/404; A61K31/4166; A61K31/4184; A61K31/4409; A61K31/4706; A61K31/513; A61K31/52; A61K31/53; A61K31/661; A61K38/00; A61K45/00; A61P35/00; A61P43/00; C07C237/06; C07C243/28; C07C243/34; C07C245/04; C07C255/58; C07C257/14; C07C271/64; C07C275/08; C07C275/16; C07C281/12; C07C281/14; C07C311/03; C07C317/28; C07C327/42; C07C337/08; C07D209/14; C07D213/81; C07D215/46; C07D233/72; C07D233/76; C07D233/91; C07D239/50; C07D239/54; C07D239/56; C07D251/22; C07D307/52; C07D473/24; C07F9/24; C07K5/023; C07K5/062; C07K5/083; C07K5/103; C12N9/99
Domestic Patent References:
| JP2005525090A | ||||
| JP2003523166A | ||||
| JP2007517886A | ||||
| JP2008522639A |
Foreign References:
| US2673859 |
Other References:
Silvio E. Perea, Osvaldo Reyes, Yaquelin Puchades,Antitumor Effect of a Novel Proapototic Peptide that Impairs the Phosphorylation by the Protein Kinase 2 (Casein Kinase 2),Cancer Research,米国,American Association for Cancer Research,2004年10月 1日,vol.64, No.19,p.7127-7129
Thomas P. Johnston, Geroge S. McCaler, Pamela S. Opliger, John A. Montgomery,The Synthesis of Potential Anticancer Agents. XXXVI. N-Nitrosoureas. II. Haloalkyl Derivatives,Journal of Medicinal Chemistry,米国,ACS Publications,1966年11月,vol.9, No.6,p.892-911
Abelardo P. Martinez, William W. Lee,Some Semicarbazones and Thiosemicarbazones,Journal of Medicinal Chemistry,米国,ACS Publications,1967年11月,vol.10, No.6,p.1192
Lindley A. Cates,Phosphorus-Nitrogen Compounds. VII Urea, Aziridinecarboxamide, and Semicarbazide Derivatives,Journal of Medicinal Chemistry,米国,ACS Publications,1967年 9月,vol.10, No.5,p.924-927
M. S. Kharasch, P. O. Tawney,Factors Influencing the Course and Mechanism of Grignard Reactions. XVI. An Isomer of Isophorone-Δ3,4-3,5,5-Trimethylcyclohexenone,Journal of the American Chemical Society,米国,ACS Publications,1945年 1月,vol.67, No.1,p.128-130
Leon L. Gershbein, Herman Pines, V. N. Ipatieff,Reactions of Isopropyl Alcohol in the Presence of Catalysts Containing Magnesium Oxide,Journal of the American Chemical Society,米国,ACS Publications,1947年11月,vol.69, No.11,p.2888-2893
Xinqi Zhao, Yuh-Loo Chang, Frank W. Fowler, Joseph W. Lauher,An approach to the Design of Molecular Solids. The Ureylenedicarboxylic acids,Journal of the American Chemical Society,米国,ACS Publications,1990年 8月,vol.112, No.18,p.6627-6634
Walter Kimel, Arthur C. Cope,The Rearrangement of Allyl-Type Esters of β-Keto Acids,Journal of the American Chemical Society,米国,ACS Publications,1943年10月,vol.65, No.10,p.1992-1998
Peter P. T. Sah, T. C. Daniels,Thiosemicarbazide as a Reagent for the Identification of Aldehydes, Ketones, and Quinones,Recueil des Travaux Chimiques des Pays-Bas,ドイツ,1950年,vol.69,p.1545-1556
Justus K. Landquist,Oxidative Cyclisation of Ketone Thiosemicarbazones. Part II. Derivatives of Phenoxyacetone,Journal of the Chemical Society C. Organic Chemistry,英国,RSC Publishing,1970年,p.323-324
Thomas P. Johnston, Geroge S. McCaler, Pamela S. Opliger, John A. Montgomery,The Synthesis of Potential Anticancer Agents. XXXVI. N-Nitrosoureas. II. Haloalkyl Derivatives,Journal of Medicinal Chemistry,米国,ACS Publications,1966年11月,vol.9, No.6,p.892-911
Abelardo P. Martinez, William W. Lee,Some Semicarbazones and Thiosemicarbazones,Journal of Medicinal Chemistry,米国,ACS Publications,1967年11月,vol.10, No.6,p.1192
Lindley A. Cates,Phosphorus-Nitrogen Compounds. VII Urea, Aziridinecarboxamide, and Semicarbazide Derivatives,Journal of Medicinal Chemistry,米国,ACS Publications,1967年 9月,vol.10, No.5,p.924-927
M. S. Kharasch, P. O. Tawney,Factors Influencing the Course and Mechanism of Grignard Reactions. XVI. An Isomer of Isophorone-Δ3,4-3,5,5-Trimethylcyclohexenone,Journal of the American Chemical Society,米国,ACS Publications,1945年 1月,vol.67, No.1,p.128-130
Leon L. Gershbein, Herman Pines, V. N. Ipatieff,Reactions of Isopropyl Alcohol in the Presence of Catalysts Containing Magnesium Oxide,Journal of the American Chemical Society,米国,ACS Publications,1947年11月,vol.69, No.11,p.2888-2893
Xinqi Zhao, Yuh-Loo Chang, Frank W. Fowler, Joseph W. Lauher,An approach to the Design of Molecular Solids. The Ureylenedicarboxylic acids,Journal of the American Chemical Society,米国,ACS Publications,1990年 8月,vol.112, No.18,p.6627-6634
Walter Kimel, Arthur C. Cope,The Rearrangement of Allyl-Type Esters of β-Keto Acids,Journal of the American Chemical Society,米国,ACS Publications,1943年10月,vol.65, No.10,p.1992-1998
Peter P. T. Sah, T. C. Daniels,Thiosemicarbazide as a Reagent for the Identification of Aldehydes, Ketones, and Quinones,Recueil des Travaux Chimiques des Pays-Bas,ドイツ,1950年,vol.69,p.1545-1556
Justus K. Landquist,Oxidative Cyclisation of Ketone Thiosemicarbazones. Part II. Derivatives of Phenoxyacetone,Journal of the Chemical Society C. Organic Chemistry,英国,RSC Publishing,1970年,p.323-324
Attorney, Agent or Firm:
Hideto Asamura
Hajime Asamura
Naganuma Akio
Yukihiro Ikeda
Hajime Asamura
Naganuma Akio
Yukihiro Ikeda
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