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Title:
喘息および関連疾患を含むアトピー性アレルギーを処置するための標的としての喘息関連因子
Document Type and Number:
Japanese Patent JP2004506599
Kind Code:
A
Abstract:
This invention relates to methods for treating asthma or allergy in a mammal by administering a 3-aminosteroid compound to a mammal in need thereof. The 3-aminosteroid compound being capable of down regulating the IL-9 pathway and alleviating asthmatic responses to allergen. Exemplary 3-aminosteroid compounds used in the methods of the invention include compounds having the chemical formula (I), wherein X, R1, R2, R3, and R4 groups are as defined herein. The invention also relates to certain novel compounds of formula (I). Moreover, the invention also provides methods for identifying an immunomodulatory 3-aminosteroid compound.

Inventors:
Levitt, Locy.
Nicolaides, Nicholas
Kinney, William A.
Steve, Jones
Application Number:
JP2001543570A
Publication Date:
March 04, 2004
Filing Date:
December 11, 2000
Export Citation:
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Assignee:
Genera Corporation
International Classes:
G01N33/50; A61K31/56; A61K31/575; A61K31/58; A61K31/66; A61K31/662; A61P1/04; A61P11/00; A61P11/02; A61P11/06; A61P17/04; A61P27/16; A61P29/00; A61P37/08; A61P43/00; C07J17/00; C07J41/00; C07J43/00; C07J51/00; C12Q1/06; C12Q1/68; G01N33/15; (IPC1-7): A61K31/575; A61K31/58; A61K31/662; A61P1/04; A61P11/00; A61P11/02; A61P11/06; A61P17/04; A61P27/16; A61P29/00; A61P37/08; A61P43/00; C07J41/00; C07J43/00; C12Q1/06; C12Q1/68; G01N33/15; G01N33/50
Foreign References:
WO1999015656A21999-04-01
US5908839A1999-06-01
WO1996040151A11996-12-19
US5847172A1998-12-08
US5840740A1998-11-24
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita



 
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