Title:
An authorization method of the abundance associated diseases in TDP-43 cell
Document Type and Number:
Japanese Patent JP6155533
Kind Code:
B2
Abstract:
The present invention aims to develop and provide a method for identifying a disease associated with the abundance of TDP-43 in cells and a method for producing a TDP-43 binding inhibitor. By measuring the abundance of a measurement substance, the amount of binding between a measurement substance and TDP-43, etc. in cells obtained from a subject, it is identified whether or not the subject is suffering from a disease associated with the abundance of TDP-43 in cells. Also, a drug which can significantly reduce the binding between a measurement substance and TDP-43 is produced by adding a drug candidate substance.
Inventors:
Nobuhiro Takahashi
Keiichi Izumikawa
Hideaki Ishikawa
Yoshikawa Harutaka
Isoaki Toshiaki
Mango Taoka
Hiroshi Nakayama
Keiichi Izumikawa
Hideaki Ishikawa
Yoshikawa Harutaka
Isoaki Toshiaki
Mango Taoka
Hiroshi Nakayama
Application Number:
JP2014502381A
Publication Date:
July 05, 2017
Filing Date:
February 28, 2013
Export Citation:
Assignee:
National University Corporation Tokyo University of Agriculture and Technology
Tokyo Metropolitan University
Tokyo Metropolitan University
International Classes:
C12Q1/68; A61K31/7088; A61K38/17; A61P25/00; A61P25/16; A61P25/28; G01N33/53
Domestic Patent References:
| JP2009247219A |
Foreign References:
| US20110203007 |
Other References:
AYALA, Youhna M. et al.,Human, Drosophila, and C.elegans TDP43: nucleic acid binding properties and splicing regulatory function.,J. Mol. Biol.,2005年,Vol. 348,pp. 575-588
Jeffrey D. Rothstein et al.,Abnormal excitatory amino acid metabolism in amyotrophic lateral sclerosis.,Annals of Neurology,1990年,Vol. 28,pp. 18-25
Michael J. Strong et al.,TDP43 is a human low molecular weight neurofilament (hNFL)mRNA-binding protein.,Mol. Cell. Neurosci.,2007年,Vol. 35,pp. 320-327
Michael J. Strong,The evidence for altered RNA metabolism in amyotrophic lateral sclerosis (ALS).,Journal of the Neurological Sciences,2010年,Vol. 288,pp. 1-12
Ya-Fei Xu et al.,Wild-Type Human TDP-43 Expression Causes TDP-43 Phosphorylation, Mitochondrial Aggregation, Motor Deficits, and Early Mortality in Transgenic Mice.,The Journal of Neuroscience,2010年,Vol. 30,pp. 10851-10859
Xiu Shan et al.,Altered distributions of Gemini of coiled bodies andmitochondria in motor neurons of TDP-43 transgenic mice.,PNAS,2010年,Vol. 107,pp. 16325-16330
有泉優子,TDP43の発現抑制による細胞内小器官の形態変化,新潟医学会雑誌,2011年,第125巻,第482-497頁
Jinsheng Lu et al.,Mitochondrial dysfunction in human TDP-43 transfected NSC34 cell lines and theprotective effect of dimethoxy curcumin.,Brain Research Bulletin,2012年 9月,Vol. 89,pp. 185-190
Jeffrey D. Rothstein et al.,Abnormal excitatory amino acid metabolism in amyotrophic lateral sclerosis.,Annals of Neurology,1990年,Vol. 28,pp. 18-25
Michael J. Strong et al.,TDP43 is a human low molecular weight neurofilament (hNFL)mRNA-binding protein.,Mol. Cell. Neurosci.,2007年,Vol. 35,pp. 320-327
Michael J. Strong,The evidence for altered RNA metabolism in amyotrophic lateral sclerosis (ALS).,Journal of the Neurological Sciences,2010年,Vol. 288,pp. 1-12
Ya-Fei Xu et al.,Wild-Type Human TDP-43 Expression Causes TDP-43 Phosphorylation, Mitochondrial Aggregation, Motor Deficits, and Early Mortality in Transgenic Mice.,The Journal of Neuroscience,2010年,Vol. 30,pp. 10851-10859
Xiu Shan et al.,Altered distributions of Gemini of coiled bodies andmitochondria in motor neurons of TDP-43 transgenic mice.,PNAS,2010年,Vol. 107,pp. 16325-16330
有泉優子,TDP43の発現抑制による細胞内小器官の形態変化,新潟医学会雑誌,2011年,第125巻,第482-497頁
Jinsheng Lu et al.,Mitochondrial dysfunction in human TDP-43 transfected NSC34 cell lines and theprotective effect of dimethoxy curcumin.,Brain Research Bulletin,2012年 9月,Vol. 89,pp. 185-190
Attorney, Agent or Firm:
Yusuke Hiraki
Satoshi Fujita
Satoshi Fujita
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