Title:
An aza-adamantane derivative and its use
Document Type and Number:
Japanese Patent JP6180432
Kind Code:
B2
Abstract:
The present invention relates to certain amide derivatives that have the ability to inhibit 11-beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD-1) and which are therefore useful in the treatment of certain disorders that can be prevented or treated by inhibition of this enzyme. In addition the invention relates to the compounds, methods for their preparation, pharmaceutical compositions containing the compounds and the uses of these compounds in the treatment of certain disorders. It is expected that the compounds of the invention will find application in the treatment of conditions such as non-insulin dependent type 2 diabetes mellitus (NIDDM), insulin resistance, obesity, impaired fasting glucose, impaired glucose tolerance, lipid disorders such as dyslipidemia, hypertension and as well as other diseases and conditions.
Inventors:
Lao, Jagannat Madanahari Langanath
Venkateshham, Uppalla
Doppala Pudy, Shivanageswararao
Kenche Gouda, Bome Gouda
Fernando, George
George, Jenson
Madhavan, G.R.
Naidu, Goal Paidap
Kadam Bali, B.S. Naga Rajesh
Jagannat, S
Manivannan, Earl
Kumaru, Tea Sentil
Kumaru, Be Shiva Sentil
Marika Juna, Ray
Venkateshham, Uppalla
Doppala Pudy, Shivanageswararao
Kenche Gouda, Bome Gouda
Fernando, George
George, Jenson
Madhavan, G.R.
Naidu, Goal Paidap
Kadam Bali, B.S. Naga Rajesh
Jagannat, S
Manivannan, Earl
Kumaru, Tea Sentil
Kumaru, Be Shiva Sentil
Marika Juna, Ray
Application Number:
JP2014548340A
Publication Date:
August 16, 2017
Filing Date:
December 21, 2012
Export Citation:
Assignee:
Conexios Life Sciences Private Limited
International Classes:
C07D451/14; A61K31/439; A61K31/4545; A61K31/4709; A61P1/04; A61P3/04; A61P3/06; A61P3/08; A61P3/10; A61P5/50; A61P7/00; A61P9/00; A61P9/02; A61P9/04; A61P9/06; A61P9/10; A61P9/12; A61P13/02; A61P13/12; A61P15/00; A61P19/10; A61P21/00; A61P25/00; A61P25/18; A61P25/24; A61P25/28; A61P27/02; A61P27/06; A61P29/00; A61P31/12; A61P43/00; C07D519/00
Domestic Patent References:
| JP2006522746A | ||||
| JP2009519986A | ||||
| JP2008526874A | ||||
| JP2010526777A |
Foreign References:
| EP1125922A1 | ||||
| WO2011030349A1 |
Attorney, Agent or Firm:
Ryoichi Takaoka
Nao Oda
Kaoru Takahashi
Nao Oda
Kaoru Takahashi
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