Title:
腫瘍壊死因子産生の阻害剤としてのベンゾナフトアズレン類及びその製造用中間体
Document Type and Number:
Japanese Patent JP2005526827
Kind Code:
A
Abstract:
The present invention relates to benzonaphthoazulene derivatives of tiophene class, to their pharmacologically acceptable salts and solvates, to processes and intermediates for the preparation thereof as well as to their antiinflammatory effects, especially to the inhibition of tumor necrosis factor-alpha (TNF-alpha) production and the inhibition of interleukin-1 (IL-1) production as well as to their analgetic action.
Inventors:
Mersep, Muraden
Methic, Milan
Pesic, Dayana
Osimek, Evanna
Troyko, Rudolph
Methic, Milan
Pesic, Dayana
Osimek, Evanna
Troyko, Rudolph
Application Number:
JP2003582158A
Publication Date:
September 08, 2005
Filing Date:
April 09, 2003
Export Citation:
Assignee:
PRIVA-Istra Tsv Atsky Institute Day Oh Oh
International Classes:
C07D495/04; A61K31/38; A61K31/381; A61K31/4025; A61K31/4535; A61K31/5377; A61P1/04; A61P9/00; A61P11/00; A61P11/06; A61P13/12; A61P17/00; A61P17/06; A61P19/02; A61P19/06; A61P25/00; A61P29/00; A61P31/04; A61P31/12; A61P31/18; A61P37/02; A61P37/08; A61P43/00; C07D333/80; C07D337/16; C07D413/02; (IPC1-7): C07D495/04; A61K31/381; A61K31/4025; A61K31/4535; A61K31/5377; A61P1/04; A61P9/00; A61P11/00; A61P11/06; A61P13/12; A61P17/00; A61P17/06; A61P19/02; A61P19/06; A61P25/00; A61P29/00; A61P31/04; A61P31/12; A61P31/18; A61P37/02; A61P37/08; A61P43/00
Attorney, Agent or Firm:
Takao Hamano
Morita Tetsuji
Teruichi Hirai
Morita Tetsuji
Teruichi Hirai