Title:
A base material, a system, and a method for array composition and biomolecule analysis
Document Type and Number:
Japanese Patent JP6275152
Kind Code:
B2
Abstract:
The present invention relates to methods of attaching a coupling molecule (e.g. a peptide, an amino acid, ...) to a substrate comprising a plurality of carboxylic acid groups for linking to a coupling molecule; contacting said substrate with a carboxylic acid activating compound formulation comprising a carbodiimide precursor (i.e. a tetrazole thione), wherein said carbodiimide precursor converts to a carbodiimide upon exposure to electromagnetic radiation at a defined wavelength; selectively exposing said carboxylic acid activating compound formulation to the electromagnetic radiation, thereby generating said carbodiimide and activating the carboxylic acid groups to form carbonyl groups on said substrate at a selectively exposed area; contacting the substrate with a coupling formulation comprising a coupling molecule and a solvent; coupling the coupling molecule to at least one of said plurality of carbonyl groups at said selectively exposed area. The invention also relates to corresponding carboxylic acid activating formulations.
Inventors:
Raja Sekaran John Jay.
Jayara Man Vasance
One Tian Hao
Bakan
Krishnamurty Harry Krishnan
Jayara Man Vasance
One Tian Hao
Bakan
Krishnamurty Harry Krishnan
Application Number:
JP2015542794A
Publication Date:
February 07, 2018
Filing Date:
November 14, 2013
Export Citation:
Assignee:
Vibrant Holdings Limited Liability Company
International Classes:
G01N33/53; C07F5/02; C07K17/14; C09K3/00; G01N33/543; G01N33/547
Domestic Patent References:
| JP2002502698A | ||||
| JP2003342354A | ||||
| JP2005264156A |
Foreign References:
| US20070154946 | ||||
| WO1994028075A1 |
Other References:
XUN SUN et al.,Bicyclic Guanidinium Tetraphenylborate: A Photobase Generator and A Photocatalyst for Living Anionic Ring-Opening Polymerization and Cross-Linking of Polymeric Materials Containing Ester and Hydroxy Groups,J. AM. CHEM. SOC.,2008年 7月,Vol.130,No.26,pp.8130-8131
Attorney, Agent or Firm:
Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto