Title:
アポリポタンパク質B阻害剤としてのビアリールカルボキサミド化合物
Document Type and Number:
Japanese Patent JP2004532856
Kind Code:
A
Abstract:
The present invention relates to compounds of the formula (I) wherein X<1 >is wherein R<1>, R<2 >and R<10 >are independently hydrogen or a suitable substituent; R<11 >and R<12 >are independently hydrogen or a suitable substituent; R is unsaturated 5 to 6-membered heteromonocyclic group; A is direct bond or -NH-; X<2 >is monocyclic arylene, unsaturated 5 to 6-membered heteromonocyclic group or cycloalkenylene; Y is bivalent group selected from ethylene, trimethylene and vinylene, wherein CH<2 >is optionally replaced by NH or O, and CH is optionally replaced by N; and Z is -(CH2)n-, -CO-(CH2)m-, -CH=CH- or -CO-NH-, wherein n is 1, 2 or 3 and m is 1 or 2, or a salt thereof. The compounds of the present invention inhibit apolipoprotein B (Apo B) secretion and are useful as a medicament for prophylactic and treatment of diseases or conditions resulting from elevated circulating levels of Apo B.
Inventors:
High Sugi Shou
Takeshi Terasawa
Inoue Zen Ladies
Eiko Nakamura
Nagayoshi Akira
Yoshiro Furukawa
Mikami Masafumi
Kazumasa Higami
Ryo Otsubo
Takeshi Terasawa
Inoue Zen Ladies
Eiko Nakamura
Nagayoshi Akira
Yoshiro Furukawa
Mikami Masafumi
Kazumasa Higami
Ryo Otsubo
Application Number:
JP2002587427A
Publication Date:
October 28, 2004
Filing Date:
April 09, 2002
Export Citation:
Assignee:
Fujisawa Pharmaceutical Co., Ltd.
Daiso Co., Ltd.
Daiso Co., Ltd.
International Classes:
C07D265/36; A61K31/404; A61K31/4196; A61K31/427; A61K31/433; A61K31/4439; A61K31/4545; A61K31/4709; A61K31/497; A61K31/498; A61K31/506; A61K31/536; A61K31/5377; A61K31/538; A61K31/541; A61P1/18; A61P3/00; A61P3/04; A61P3/06; A61P3/10; A61P9/00; A61P9/08; A61P9/10; A61P43/00; C07C271/24; C07D207/335; C07D209/08; C07D209/44; C07D213/30; C07D213/38; C07D213/40; C07D213/50; C07D213/56; C07D213/73; C07D213/74; C07D213/75; C07D213/81; C07D217/04; C07D217/18; C07D217/20; C07D233/54; C07D239/26; C07D239/42; C07D249/08; C07D277/24; C07D277/28; C07D277/40; C07D277/46; C07D277/48; C07D295/033; C07D295/135; C07D295/15; C07D295/155; C07D295/192; C07D295/205; C07D401/04; C07D401/06; C07D401/12; C07D401/14; C07D403/06; C07D403/14; C07D405/06; C07D409/06; C07D409/12; C07D409/14; C07D413/06; C07D413/14; C07D417/06; C07D417/12; C07D417/14; C07D207/32; C07D295/02; (IPC1-7): C07D209/08; A61K31/404; A61K31/4196; A61K31/427; A61K31/433; A61K31/4439; A61K31/4545; A61K31/4709; A61K31/497; A61K31/498; A61K31/506; A61K31/536; A61K31/5377; A61K31/538; A61K31/541; A61P1/18; A61P3/00; A61P3/04; A61P3/06; A61P3/10; A61P9/00; A61P9/08; A61P9/10; A61P43/00; C07D265/36; C07D401/06; C07D401/12; C07D401/14; C07D403/06; C07D403/14; C07D409/14; C07D413/06; C07D413/14; C07D417/06; C07D417/14
Attorney, Agent or Firm:
Takashima Ichi