Title:
(-)-ベルベノン誘導体
Document Type and Number:
Japanese Patent JP4878679
Kind Code:
B2
Abstract:
A description is given here of novel solid and stable derivatives of (-)-verbenone having formula (I) wherein, when X=O Z=H, =CHAr, =C(OH)COOEt, =NOR; Y=H, NH2, NH3+X1-, NHCOAr, NHCOR, NHCONHR, NHCONHAr, X1-=pharmaceutically acceptable anion; Ar-aryl or heteroaryl, preferably phenyl, 4-chlorophenyl, 2-furyl, 2-thienyl, 2-hydroxyphenyl, 2-acetoxyphenyl; R=H, C1-C4 alkyl, C4-C6 cycloalkyl, CH2COOH, CH2COOEt, CH2COCH3, CH2CN, CH2COCH2COOEt, CH2C6H5; and, when X=dimethylamino, diethylamino, pyrrolidino, piperidino or morpholino: Y=H; Z=H, CONHAr, COHNR; Ar=aryl, preferably phenyl; R=H, C1-C4 alkyl, C4-C6 cycloakyl. A description is also given of the processes for the preparation of these derivatives and of the novel intermediates used in those processes. The novel derivatives are characterized by their solubility in water; some of them also have a high anti-inflammatory activity.
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Inventors:
Mora Paolo Corbi
Angelo Lanice
Angelo Lanice
Application Number:
JP2000612255A
Publication Date:
February 15, 2012
Filing Date:
April 13, 2000
Export Citation:
Assignee:
Eufar Group Society A Responsor Billita Limiteda
International Classes:
C07C49/683; A61K31/122; C07D295/02; A61K31/13; A61K31/15; A61K31/17; A61K31/192; A61K31/222; A61K31/40; A61P11/00; A61P11/08; A61P29/00; C07C45/34; C07C45/74; C07C49/433; C07C69/738; C07C225/20; C07C235/62; C07C251/42; C07C251/60; C07C275/28; C07C275/38; C07D295/033; C07D295/14; C07D295/155
Domestic Patent References:
| JPS52151156A | 1977-12-15 |
Attorney, Agent or Firm:
Yoshikazu Tani
Kazuo Abe
Kazuo Abe