Title:
The benzoazo Lil piperazine derivative which has mGluR1- and mGluR5-antagonist activity
Document Type and Number:
Japanese Patent JP6005712
Kind Code:
B2
Abstract:
A compound of formula: wherein Ar1, A, R3, X, and m are as disclosed herein and Ar2 is a benzothiazolyl, benzooxazolyl, or benzoimidazolyl group or a pharmaceutically acceptable salt thereof (a “Benzoazolylpiperazine Compound”), compositions comprising a Benzoazolylpiperazine Compound, and methods for treating or preventing pain, UI, an ulcer, IBD, IBS, an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, stroke, a seizure, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington's chorea, amyotrophic lateral sclerosis, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia, or depression in an animal comprising administering to an animal in need thereof an effective amount of a Benzoazolylpiperazine Compound are disclosed.
Inventors:
Sun
Tafesse, Lakey
Victor, Sam
Tafesse, Lakey
Victor, Sam
Application Number:
JP2014249728A
Publication Date:
October 12, 2016
Filing Date:
December 10, 2014
Export Citation:
Assignee:
Euro-Certique S.A.
International Classes:
C07D401/12; A61K31/495; A61K31/496; A61P1/04; A61P1/08; A61P13/00; A61P13/02; A61P17/04; A61P21/02; A61P25/04; A61P25/06; A61P25/08; A61P25/14; A61P25/16; A61P25/18; A61P25/22; A61P25/24; A61P25/28; A61P25/30; A61P27/02; A61P29/00; A61P43/00; C07D401/14; C07D403/12; C07D413/12; C07D417/12; C07D417/14
Domestic Patent References:
| JP11199573A | ||||
| JP2001048879A | ||||
| JP2013209380A |
Foreign References:
| WO2001057008A1 | ||||
| WO2002008221A1 | ||||
| WO2001057008A1 |
Attorney, Agent or Firm:
Hiroshi Kobayashi
Norio Omori
Kyoei Sugiyama
Yasuhito Suzuki
Norio Omori
Kyoei Sugiyama
Yasuhito Suzuki