Title:
胆汁酸金属イオン封鎖剤およびその製造方法
Document Type and Number:
Japanese Patent JP2009520835
Kind Code:
A
Abstract:
The present invention describes a copolymer comprising multiple unsaturations, which are obtained by polymerization of dimethyl beta-cyclodextrin inclusion complex of monomer containing multiple vinyl unsaturation and amine functional monomer. These water soluble copolymers containing unsaturation sites, crosslinked in the presence of bile acid template. This novel sequential polymerization and crosslinked process enhances the rebinding capacity of the bile acid sequestrant for the bile acid used as the template during crosslinking step and also selectivity over other bile acids, in comparison to the polymers synthesized by the conventional simultaneous polymerization/crosslinking method.
Inventors:
Gore, Mahesh Ambadas
Kurkany, Mohan Gopaldas
Kurkany, Mohan Gopaldas
Application Number:
JP2008530641A
Publication Date:
May 28, 2009
Filing Date:
September 12, 2006
Export Citation:
Assignee:
COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH
International Classes:
C08F220/34; A61K31/785; A61P1/16; A61P9/10; C08F220/56; C08F226/02
Domestic Patent References:
| JPH10195108A | 1998-07-28 | |||
| JP2001521890A | 2001-11-13 | |||
| JP2003321515A | 2003-11-14 | |||
| JP2007516300A | 2007-06-21 | |||
| JP2007538131A | 2007-12-27 | |||
| JP2008518074A | 2008-05-29 | |||
| JP2003147025A | 2003-05-21 |
Foreign References:
| WO2005014671A1 | 2005-02-17 |
Attorney, Agent or Firm:
Takehiko Suzue
Kurata Masatoshi
Satoshi Kono
Makoto Nakamura
Takashi Mine
Yoshihiro Fukuhara
Toshio Shirane
Sadao Muramatsu
Nobuhisa Nogawa
Katsu Sunagawa
Ryo Hashimoto
Tetsuya Kazama
Kurata Masatoshi
Satoshi Kono
Makoto Nakamura
Takashi Mine
Yoshihiro Fukuhara
Toshio Shirane
Sadao Muramatsu
Nobuhisa Nogawa
Katsu Sunagawa
Ryo Hashimoto
Tetsuya Kazama