Title:
ｃ−Ｍｅｔモジュレーターおよびその使用
Document Type and Number:
Japanese Patent JP5694501
Kind Code:
B2
Abstract:
The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. More specifically, the invention provides quinazolines and quinolines which inhibit, regulate and/or modulate kinase receptor, particularly c-Met, KDR, c-Kit, flt-3 and flt-4, signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions. The present invention also provides methods for making compounds as mentioned above, and compositions which contain these compounds.
Inventors:
Lincoln Banen
Divas Suze-Min Chan
Jeff Chen
Lisa Esther Dull Line Pull
Timothy Patrick Forsythe
Thai Fat Huin
Bus Jamarama Madaka
Richard George Cooley
James William Leech
Morrison B. Mac
Graceman
Larry W. Man
John M. Eggplant
Jason Jeverus Parks
Craig Stacy Takeuchi
Wang Yong
Weish
Divas Suze-Min Chan
Jeff Chen
Lisa Esther Dull Line Pull
Timothy Patrick Forsythe
Thai Fat Huin
Bus Jamarama Madaka
Richard George Cooley
James William Leech
Morrison B. Mac
Graceman
Larry W. Man
John M. Eggplant
Jason Jeverus Parks
Craig Stacy Takeuchi
Wang Yong
Weish
Application Number:
JP2013268454A
Publication Date:
April 01, 2015
Filing Date:
December 26, 2013
Export Citation:
Assignee:
Exelixis, Inc.
International Classes:
C07D215/22; A61K31/47; A61K31/535; C07D215/16; C07D215/20; C07D215/38; C07D239/88; C07D401/12; C07D401/14; C07D413/00; C07D413/12; C07D417/12; A61K
Domestic Patent References:
| JP2003509499A | ||||
| JP11158149A | ||||
| JP2002030083A | ||||
| JP4638436B2 | ||||
| JP5185331B2 | ||||
| JP5185332B2 | ||||
| JP5325172B2 | ||||
| JP5325173B2 | ||||
| JP2014055191A | ||||
| JP2014055190A |
Foreign References:
| WO2003000660A1 | ||||
| WO2001047890A1 | ||||
| WO2000043366A1 | ||||
| WO2002032872A1 | ||||
| WO2003033472A1 | ||||
| WO2004060373A1 | ||||
| WO2003093238A1 |
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Natsuki Morishita