Title:
細胞
Document Type and Number:
Japanese Patent JP6833727
Kind Code:
B2
Abstract:
The present invention relates to a cell which comprises a chimeric antigen receptor (CAR) and a signal transduction modifying protein, selected from one of the following:(i) a truncated protein which comprises an SH2 domain from a protein which binds a phosphorylated immunoreceptor tyrosine-based activation motif (ITAM), but lacks a kinase domain;(ii) a truncated protein which comprises an SH2 domain from a protein which binds a phosphorylated immunoreceptor tyrosine-based inhibition motif (ITIM) but lacks a phosphatase domain;(iii) a fusion protein which comprises (a) an SH2 domain from a protein which binds a phosphorylated immunoreceptor tyrosine-based activation motif (ITAM) or from a protein which binds a phosphorylated immunoreceptor tyrosine-based inhibition motif (ITIM); and (ii) a heterologous domain.
Inventors:
Pule, martin
Sean, Cordoba
Thomas, Simon
Con, chi
Sean, Cordoba
Thomas, Simon
Con, chi
Application Number:
JP2017562027A
Publication Date:
February 24, 2021
Filing Date:
May 31, 2016
Export Citation:
Assignee:
UCL Business Limited
International Classes:
C12N15/62; A61K35/17; A61K39/395; A61P35/00; C12N5/10; C12N15/867
Foreign References:
| WO2015075468A1 | ||||
| WO2016056228A1 |
Other References:
上原記念生命科学財団研究報告集,2014年12月 5日,Vol. 28,pp. 1-4,Article 107
MOLECULAR AND CELLULAR BIOLOGY,2003年 9月,Vol. 23, No. 17,pp. 6291-6299
MOLECULAR AND CELLULAR BIOLOGY,1996年 5月,Vol. 16, No. 5,pp. 2255-2263
MOLECULAR AND CELLULAR BIOLOGY,2003年 9月,Vol. 23, No. 17,pp. 6291-6299
MOLECULAR AND CELLULAR BIOLOGY,1996年 5月,Vol. 16, No. 5,pp. 2255-2263
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto