Title:
クロマトグラフ質量分析装置
Document Type and Number:
Japanese Patent JP7400698
Kind Code:
B2
Abstract:
In a chromatograph mass spectrometer having a measurement unit (1) including a chromatograph is combined with a tandem mass spectrometry section capable of an MS/MS analysis, a controller (40) performs chromatograph mass spectrometry by controlling the measurement unit so as to operate the tandem mass spectrometry section to cyclically perform analysis cycles, where each of the analysis cycles includes a first mass spectrometric analysis in which a measurement of ions is performed over a predetermined m/z range and an MS/MS analysis by DIA in which ions included within each of a plurality of windows formed by dividing the m/z range are designated as a precursor ion. A window selector (42, 43) selects, during an execution of an analysis cycle, a window among the plurality of windows for an MS/MS analysis by DDA which is irregularly performed in an ongoing analysis cycle, based on intensity information obtained for each of the plurality of windows from an MS/MS spectrum acquired by the MS/MS analysis by DIA. A precursor-ion determiner (44) determines a precursor ion corresponding to the window selected by the window selector in a mass spectrum acquired by the first mass spectrometric analysis in the ongoing analysis cycle, based on peak information included within the m/z range of the window. A data-dependent-acquisition condition setter (45) informs the controller of the precursor ion determined by the precursor-ion determiner, as the precursor ion for the MS/MS analysis by DDA which is irregularly performed in the ongoing analysis cycle.
Inventors:
Kazuma Maeda
Toshiya Matsubara
Toshiya Matsubara
Application Number:
JP2020190526A
Publication Date:
December 19, 2023
Filing Date:
November 16, 2020
Export Citation:
Assignee:
SHIMADZU CORPORATION
International Classes:
H01J49/00; G01N27/62; H01J49/40; H01J49/42
Domestic Patent References:
| JP2013537312A | ||||
| JP2020527695A | ||||
| JP2020532738A |
Foreign References:
| US20180350576 | ||||
| US9911585 | ||||
| WO2019012589A1 | ||||
| US20200264142 |
Attorney, Agent or Firm:
Patent Attorney Corporation Kyoto International Patent Office