Title:
A chromatography medium and a method
Document Type and Number:
Japanese Patent JP6278929
Kind Code:
B2
Abstract:
Adsorptive media for chromatography, particularly ion-exchange chromatography, derived from a shaped fiber. In certain embodiments, the functionalized shaped fiber presents a fibrillated or ridged structure which greatly increases the surface area of the fibers when compared to ordinary fibers. Also disclosed herein is a method to add surface pendant functional groups that provides cation-exchange or anion-exchange functionality to the high surface area fibers. This pendant functionality is useful for the ion-exchange chromatographic purification of biomolecules, such as monoclonal antibodies (mAbs).
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Inventors:
David Jaworski
John Amara
Jokin Umana
William Cataldo
Mikhail Kozlov
Matthew Stone
John Amara
Jokin Umana
William Cataldo
Mikhail Kozlov
Matthew Stone
Application Number:
JP2015135562A
Publication Date:
February 14, 2018
Filing Date:
July 06, 2015
Export Citation:
Assignee:
EMD Millipore Corporation
International Classes:
G01N30/88; B01D15/08; B01J20/281; B01J39/18; B01J39/19; B01J39/20; B01J39/26; B01J41/12; B01J41/13; B01J41/14; B01J41/20; B01J47/016; G01N30/02
Domestic Patent References:
| JP2008510142A | ||||
| JP2000504002A | ||||
| JP8108069A | ||||
| JP2010509099A |
Foreign References:
| WO2009146321A1 | ||||
| US20050023221 |
Attorney, Agent or Firm:
Axis International Patent Business Corporation