Title:
The co-processing method and tablet of the prodrug compound and diluent base of HIV adsorption inhibitor
Document Type and Number:
Japanese Patent JP6120876
Kind Code:
B2
Abstract:
A process for the production of a formulation of HIV attachment inhibitor piperazine tris salt prodrug compound involves dissolving the prodrug compound in a solvent to form a solution; adding a first quantity of a first anti-solvent to the solution; then dispersing a first quantity of HPMC in the solution; adding a second quantity of the first anti-solvent to the solution; dispersing a second quantity of HPMC in the solution; then adding a second anti-solvent to the solution so as to crystallize the compound with the HPMC and thereby form the formulation, wherein the second anti-solvent is a combination of acetone and isopropyl acetate (IPAC). The formulation is then washed, and dried.
Inventors:
See-In Chan
Donald Sea Keenzler
Deniz Erdemill
San Kian
Tamar Rosenbaum
Donald Sea Keenzler
Deniz Erdemill
San Kian
Tamar Rosenbaum
Application Number:
JP2014549189A
Publication Date:
April 26, 2017
Filing Date:
December 18, 2012
Export Citation:
Assignee:
BRISTOL-MYERS SQUIBB COMPANY
International Classes:
A61K31/496; A61K9/16; A61K47/38; A61P31/18
Domestic Patent References:
| JP2004538249A | ||||
| JP2005512994A | ||||
| JP2007505086A |
Foreign References:
| WO2010028108A2 |
Attorney, Agent or Firm:
Samejima Mutsumi
Nagatoshi Shinagawa
Yasushi Morimoto
Nagatoshi Shinagawa
Yasushi Morimoto