Title:
Compositions and Methods for Inhibiting Bone Reabsorption
Document Type and Number:
Japanese Patent JP2004534048
Kind Code:
A
Abstract:
The present invention relates to parenteral compositions and methods for inhibiting bone resorption in a mammal while counteracting potential local irritation at injection sites. The compositions useful herein comprise the combination of a pharmaceutically effective amount of a farnesyl diphosphate synthase inhibiting bisphosphonate or a pharmaceutically-acceptable salt thereof and a pharmaceutically effective amount of a squalene synthase inhibitor.
Inventors:
Rescue, Alfredo's A
Twitter, Jiyoung Yi
Twitter, Jiyoung Yi
Application Number:
JP2003501396A
Publication Date:
November 11, 2004
Filing Date:
May 31, 2002
Export Citation:
Assignee:
MERCK & COMPANY INCOPORATED
International Classes:
A61K31/357; A61K31/663; A61K31/675; A61K45/06; A61K45/00; A61P19/08; A61P19/10; (IPC1-7): A61K45/00; A61K31/663; A61P19/08; A61P19/10
Attorney, Agent or Firm:
Yoshio Kawaguchi
Akio Ichiiri
Makoto Ono
Katsuma Osaki
Mitsuaki Tsubokura
Akio Ichiiri
Makoto Ono
Katsuma Osaki
Mitsuaki Tsubokura