Title:
ホルモン依存性疾患の予防および治療のためのプロゲステロンレセプターアンタゴニストおよび純粋なアンチエストロゲンを含んでなる組成物
Document Type and Number:
Japanese Patent JP2006528226
Kind Code:
A
Abstract:
The present invention relates to methods and uses for preventing or treating hormone-dependent diseases, in particular breast cancer, in a mammal, by a combination of an progesterone-receptor antagonist, in particular the progesterone-receptor antagonist 11²-(4-acetylphenyl)-17²-hydroxy-17±-(1,1,2,2,2-pentafluoroethyl)-estra-4,9-dien-3-one or a pharmaceutically acceptable derivative or analogue thereof, and a pure antiestrogen, in particular a compound of general formula I as defined in the specification, for instance 11²-Fluoro-17±-methyl-7±-{5-[methyl(8,8,9,9,9-pentafluorononyl)amino]pentyl}-estra-1,3,5(10)-triene-3,17²-diol. The invention further relates to pharmaceutical compositions comprising said combination.
Inventors:
Furman, Ulrike
Hoffman, Jens
Schneider, martin
G-Meister, Gerhard
Hoffman, Jens
Schneider, martin
G-Meister, Gerhard
Application Number:
JP2006529938A
Publication Date:
December 14, 2006
Filing Date:
May 27, 2004
Export Citation:
Assignee:
Schering Actien Gezel Shaft
International Classes:
A61K31/57; A61K31/567; A61K31/573; A61K45/00; A61K45/06; A61P5/30; A61P5/32; A61P5/36; A61P35/00; A61P43/00; C07J3/00; C07J7/00
Domestic Patent References:
| JP2001527088A | 2001-12-25 | |||
| JP2001503024A | 2001-03-06 |
Foreign References:
| WO2002032430A1 | 2002-04-25 | |||
| WO2002032432A1 | 2002-04-25 |
Attorney, Agent or Firm:
Atsushi Aoki
Takashi Ishida
Fukumoto product
Tetsuji Koga
Kazuhiro Nakamura
Masaya Nishiyama
Takashi Ishida
Fukumoto product
Tetsuji Koga
Kazuhiro Nakamura
Masaya Nishiyama