A compound and a constituent for checking the activity of ABL1, ABL2, and BCR-ABL1

Japanese Patent JP6080947

B2

The present invention relates to compounds of formula I: in which Y, Y1, Y4, Y5, Y6, R1, R2, R3 and R4 are defined in the Summary of the Invention; capable of inhibiting the activity of BCR-ABL1 and mutants thereof. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds in the treatment of cancers.

Ferret, Pascal
Grozfeld, Robert Martin
Darryl Brinley, Jones
Manly paul
Andrea Marzentsik
Musawi, Sariha
Pelle, Xavier Francois André
Salem bar
Shopper, joseph
Janke, wolf gang

JP2015512171A

February 15, 2017

May 09, 2013

Click for automatic bibliography generation  

Novartis Age

C07D213/56; A61K31/36; A61K31/381; A61K31/4025; A61K31/415; A61K31/4164; A61K31/426; A61K31/4418; A61K31/4439; A61K31/444; A61K31/496; A61K31/4965; A61K31/497; A61K31/505; A61K31/506; A61K31/5377; A61K45/00; A61K47/02; A61K47/04; A61K47/10; A61K47/12; A61K47/14; A61K47/20; A61K47/26; A61K47/32; A61K47/34; A61K47/36; A61K47/38; A61K47/42; A61K47/44; A61P25/28; A61P31/12; A61P43/00; C07D213/60; C07D213/78; C07D231/12; C07D233/64; C07D239/26; C07D239/34; C07D241/12; C07D241/20; C07D277/30; C07D317/60; C07D333/20; C07D333/22; C07D333/38; C07D401/04; C07D403/04; C07D405/14

JP2015516460A
JP2015520158A
JP2008515812A
JP2501388A

WO2003055477A1
WO2011060295A1
WO2011008788A1
WO2008059023A1

Hiroshi Kobayashi
Norio Omori
Saori Oga
Yasuhito Suzuki

Previous Patent: How to assess alpha particle discharge potential of a charge of a metallic material

Next Patent: DOOR GLASS GUIDE DEVICE