Title:
The compound and constituent for detection of Alzheimer's disease and associated diseases, and medical treatment
Document Type and Number:
Japanese Patent JP6140090
Kind Code:
B2
Abstract:
One aspect of the present invention relates to compounds of formula (II), compositions and methods for diagnosis and/or treatment of a subject suffering from an amyloidosis-associated pathological condition. In certain embodiments, the imaging and/or therapeutic agents of the instant invention may be administered to a subject for identification and/or treatment of amyloid deposits. A specific imaging method detects amyloid deposits by administering the imaging agent to the subject and detecting the spatial distribution of the agent. Differential accumulation of the agent is indicative of AD or an amyloidosis-associated pathological condition and can be monitored by using a PET or SPECT camera.
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Inventors:
David Earl Murray
Timothy Shoup
Hongnin Fu
Timothy Shoup
Hongnin Fu
Application Number:
JP2014046341A
Publication Date:
May 31, 2017
Filing Date:
March 10, 2014
Export Citation:
Assignee:
The General Hospital Corporation
International Classes:
C07H13/02; A61K31/047; A61K31/7024; A61K51/00; A61P25/28; C07C35/48
Foreign References:
| WO1997048711A1 | ||||
| WO2009014203A1 | ||||
| WO2007041855A1 | ||||
| US20070197452 | ||||
| WO2007119108A1 |
Other References:
LOWE, G. et al.,Synthesis of [3H]-Labelled and Unlabelled 2-Deoxy-2-fluoro-myo-inositol and 1-Deoxy-1-fluoro-scyllo-,J. Chem. Soc. Perkin Trans. 1,1991年,p.1249-1253
Attorney, Agent or Firm:
Kawaguchi International Patent Office