Title:
治療用化合物
Document Type and Number:
Japanese Patent JP2014527083
Kind Code:
A
Abstract:
The invention provides compounds of formula II:
and salts thereof, as well as pharmaceutical compositions comprising such compounds. The compounds are useful for treating cancers and Alzheimer's disease.
Inventors:
Wagner and curl E.
ジュルツカ and Peter W.
Marshall and Pamela Ey.
ジュルツカ and Peter W.
Marshall and Pamela Ey.
Application Number:
JP2014530793A
Publication Date:
October 09, 2014
Filing Date:
September 13, 2012
Export Citation:
Assignee:
Arizona Board オブ リージェンツ and アボディー Corporate オブ ザステート オブアリゾナ and acting Fau And ON ビハーフ オブ Arizona State University
International Classes:
C07C57/50; A61K31/192; A61K31/216; A61K31/4418; A61K31/505; A61P25/28; A61P35/00; A61P35/02; A61P43/00; C07C57/62; C07C59/54; C07D213/55; C07D239/28
Domestic Patent References:
| JP2002515025A | 2002-05-21 | |||
| JP2001522350A | 2001-11-13 | |||
| JP2002513756A | 2002-05-14 | |||
| JP2010503615A | 2010-02-04 | |||
| JPH10509987A | 1998-09-29 | |||
| JPH11343263A | 1999-12-14 | |||
| JP2007501800A | 2007-02-01 |
Foreign References:
| WO2007022437A2 | 2007-02-22 | |||
| WO2011103321A1 | 2011-08-25 | |||
| WO2011006157A2 | 2011-01-13 | |||
| WO2011079305A1 | 2011-06-30 |
Other References:
SANTIN EFREN PEREZ, JOURNAL OF MEDICINAL CHEMISTRY, vol. V52 N10, JPN5014010700, 2009, pages 3150 - 3158, ISSN: 0003220060
CLAUDEL, THIERRY ET AL.: "Reduction of atherosclerosis in apolipoprotein E knockout mice by activation of the retinoid X recep", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 98(5), JPN6015051013, 2001, pages 2610 - 2615, ISSN: 0003220064
FAUL, MARGARET M. ET AL.: "Synthesis of Novel Retinoid X Receptor-Selective Retinoids", JOURNAL OF ORGANIC CHEMISTRY, vol. 66(17), JPN6015051016, 2001, pages 5772 - 5782, ISSN: 0003220065
WAGNER, CARL E. ET AL.: "Modeling, Synthesis and Biological Evaluation of Potential Retinoid X Receptor(RXR) Selective Agonis", JOURNAL OF MEDICINAL CHEMISTRY, vol. 52(19), JPN6015051017, 2009, pages 5950 - 5966, ISSN: 0003220066
GARCIA JOSE, CHEMBIOCHEM - A EUROPEAN JOURNAL OF CHEMICAL BIOLOGY, vol. V10, JPN5014010701, 1 January 2009 (2009-01-01), pages 1252 - 1259, ISSN: 0003220061
BOEHM, MARCUS F ET AL.: "Synthesis and Structure-Activity Relationships of Novel Retinoid X Receptor-Selective Retinoids", JOURNAL OF MEDICINAL CHEMISTRY, vol. 37(18), JPN6015051010, 1994, pages 2930 - 2941, ISSN: 0003220062
QING, FENG-LING ET AL.: "A Suzuki Coupling Approach to Trifluoromethyl Derivative of Targretin(LGD 1069)", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 7(16), JPN6015051012, 1997, pages 2117 - 2120, ISSN: 0003220063
CLAUDEL, THIERRY ET AL.: "Reduction of atherosclerosis in apolipoprotein E knockout mice by activation of the retinoid X recep", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 98(5), JPN6015051013, 2001, pages 2610 - 2615, ISSN: 0003220064
FAUL, MARGARET M. ET AL.: "Synthesis of Novel Retinoid X Receptor-Selective Retinoids", JOURNAL OF ORGANIC CHEMISTRY, vol. 66(17), JPN6015051016, 2001, pages 5772 - 5782, ISSN: 0003220065
WAGNER, CARL E. ET AL.: "Modeling, Synthesis and Biological Evaluation of Potential Retinoid X Receptor(RXR) Selective Agonis", JOURNAL OF MEDICINAL CHEMISTRY, vol. 52(19), JPN6015051017, 2009, pages 5950 - 5966, ISSN: 0003220066
GARCIA JOSE, CHEMBIOCHEM - A EUROPEAN JOURNAL OF CHEMICAL BIOLOGY, vol. V10, JPN5014010701, 1 January 2009 (2009-01-01), pages 1252 - 1259, ISSN: 0003220061
BOEHM, MARCUS F ET AL.: "Synthesis and Structure-Activity Relationships of Novel Retinoid X Receptor-Selective Retinoids", JOURNAL OF MEDICINAL CHEMISTRY, vol. 37(18), JPN6015051010, 1994, pages 2930 - 2941, ISSN: 0003220062
QING, FENG-LING ET AL.: "A Suzuki Coupling Approach to Trifluoromethyl Derivative of Targretin(LGD 1069)", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 7(16), JPN6015051012, 1997, pages 2117 - 2120, ISSN: 0003220063
Attorney, Agent or Firm:
Shusaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto