Title:
COMPOUND TO STABILIZE RYANODINE RECEPTOR FROM ABNORMAL LEVEL CALCIUM RELEASE
Document Type and Number:
Japanese Patent JP2017088628
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide a new low molecular weight compound which target is ryanodine receptor (RyR).SOLUTION: A compound is in a specific group having Ar-furan-CH=N as a consensus structure and can be used for treatment of neurodegenerative diseases including Alzheimer's disease (AD), Parkinson's disease, Huntington disease, frontotemporal dementia, and brain damages such as traumatic brain damage (TBI), associated recognition disorder and CTE (chronic traumatic brain disorder).SELECTED DRAWING: None
Inventors:
GRACE E STUTZMANN
RUSSELL DAHL
CHRISTOPHER H KAIHO
RUSSELL DAHL
CHRISTOPHER H KAIHO
Application Number:
JP2017034947A
Publication Date:
May 25, 2017
Filing Date:
February 27, 2017
Export Citation:
Assignee:
UNIV ROSALIND FRANKLIN MEDICINE & SCIENCE
International Classes:
C07D307/52; A61K31/341; A61K31/4178; A61K31/443; A61K31/496; A61P9/00; A61P25/14; A61P25/16; A61P25/28; A61P43/00; C07D405/12
Domestic Patent References:
| JP2005533087A | 2005-11-04 | |||
| JP2007024705A | 2007-02-01 | |||
| JP2011518865A | 2011-06-30 | |||
| JP2009079001A | 2009-04-16 |
Foreign References:
| US20040006124A1 | 2004-01-08 |
Other References:
HOSOYA, T. ET AL., BIOORGANIC AND MEDICINAL CHEMISTRY, vol. 11, JPN6017042544, 2003, pages 663 - 673, ISSN: 0003678338
BETTIOL, E. ET AL., PLOS NEGLECTED TROPICAL DISEASES, vol. 3, no. 2, JPN7017003554, 2009, pages 1 - 12, ISSN: 0003678339
BETTIOL, E. ET AL., PLOS NEGLECTED TROPICAL DISEASES, vol. 3, no. 2, JPN7017003554, 2009, pages 1 - 12, ISSN: 0003678339
Attorney, Agent or Firm:
Makoto Onda
Hironobu Onda
Atsushi Honda
Hironobu Onda
Atsushi Honda