Title:
【発明の名称】酸化的損傷に伴う疾患を阻止する化合物
Document Type and Number:
Japanese Patent JP2816326
Kind Code:
B2
Abstract:
Compositions containing as the active ingredient a spin-trapping reagent, preferably alpha -phenyl butyl nitrone (PBN) or spin-trapping derivatives thereof, in a suitable pharmaceutical carrier for administration to a patient are disclosed for treating or preventin symptoms associated with aging or other conditions associated with oxidative tissue damage. Other spin-trapping agents can also be used, such as 5,5-dimethyl pyrroline N-oxide (DMPO) or alpha -(4-pyridyl 1-oxide)-N-tert-butylnitrone (POBN), and other spin-trapping derivatives thereof. These compositions and methods are useful in the treatment of age-related disorders, pre-surgical and/or pre-anesthetic preparation or administration of chemotherapeutic agents, and in the treatment of disorders or trauma of the brain, cardiovascular system, and lymphatic system. Studies in animals demonstrate that administration of compound for a two week period reduces the level of oxidized brain enzymes ot normal and restores memory to the sam level as tested in young control animals.
Inventors:
John M. Carney
Robert A. Floyd
Robert A. Floyd
Application Number:
JP17970996A
Publication Date:
October 27, 1998
Filing Date:
July 09, 1996
Export Citation:
Assignee:
OKLAHOMA MEDICAL RESEARCH FOUNDATION
University of Kentucky Research Foundation
University of Kentucky Research Foundation
International Classes:
A61K31/00; A61K31/135; A61K31/15; A61K31/16; A61K31/165; A61K31/167; A61K31/215; A61K31/22; A61K31/222; A61K31/13; A61K31/265; A61K31/325; A61K31/40; A61K31/44; A61K31/4409; A61K31/4418; A61K31/4425; A61P3/00; A61P3/10; A61P9/00; A61P9/10; A61P25/00; A61P25/02; A61P25/16; A61P25/28; A61P25/30; A61P29/00; A61P31/12; A61P39/06; A61P43/00; C07C251/32; C07C291/02; C07D207/46; C07D213/89; (IPC1-7): C07C291/02; A61K31/16; A61K31/165; A61K31/22; A61K31/265; A61K31/40; A61K31/44; C07D207/46; C07D213/89
Domestic Patent References:
| JP53116145A |
Other References:
【文献】米国特許3767818(US,A)
【文献】米国特許3775122(US,A)
【文献】英国特許出願公開1109473(GB,A)
【文献】独国特許発明273702(DE,C2)
【文献】米国特許3775122(US,A)
【文献】英国特許出願公開1109473(GB,A)
【文献】独国特許発明273702(DE,C2)
Attorney, Agent or Firm:
Shusaku Yamamoto