Title:
A constituent and the directions for an immunity toxin containing run pill Naze (RAP) which shows powerful cytotoxic activity
Document Type and Number:
Japanese Patent JP6114936
Kind Code:
B2
Abstract:
The present invention concerns methods and compositions for forming immunotoxin complexes having a high efficacy and low systemic toxicity. In preferred embodiments, the toxin moiety is a ranpirnase (Rap), such as Rap(Q). In more preferred embodiments, the immunotoxin is made using dock-and-lock (DNL) technology. The immunotoxin exhibits improved pharmacokinetics, with a longer serum half-life and significantly greater efficacy compared to toxin alone, antibody alone, unconjugated toxin plus antibody or even other types of toxin-antibody constructs. In a most preferred embodiment the construct comprises an anti-Trop-2 antibody conjugated to Rap, although other combinations of antibodies, antibody fragments and toxins may be used to form the subject immunotoxins. The immunotoxins are of use to treat a variety of diseases, such as cancer, autoimmune disease or immune dysfunction.
Inventors:
Chang, Shen-Shin
Goldenberg, David M.
Rossi, Edmund, A.
Goldenberg, David M.
Rossi, Edmund, A.
Application Number:
JP2012527065A
Publication Date:
April 19, 2017
Filing Date:
August 30, 2010
Export Citation:
Assignee:
IMMUNOMEDICS, INC.
International Classes:
C07K19/00; A61K39/395; A61P1/04; A61P1/16; A61P3/10; A61P7/04; A61P7/06; A61P9/00; A61P13/12; A61P17/02; A61P17/06; A61P19/02; A61P21/02; A61P21/04; A61P25/00; A61P25/14; A61P29/00; A61P35/00; A61P35/02; A61P37/02; A61P37/06; C07K14/00; C07K14/47; C07K16/18; C12N15/09
Domestic Patent References:
| JP2008542194A | ||||
| JP2009517337A | ||||
| JP2009519931A |
Foreign References:
| US20070086942 |
Attorney, Agent or Firm:
Ikeda adult
Masakazu Noda
Kazuhiro Yamaguchi
Hiroto Kido
Masato Ikeda
Masakazu Noda
Kazuhiro Yamaguchi
Hiroto Kido
Masato Ikeda