A constituent and a method for carrying out priming of the TH-1 response to a monocytic dendritic cell and a T-lymph cell

Title:

A constituent and a method for carrying out priming of the TH-1 response to a monocytic dendritic cell and a T-lymph cell

Document Type and Number:

Japanese Patent JP6114768

Kind Code:

B2

Abstract:

The present invention provides compositions and methods for inducing maturation of immature dendritic cells (DC) and for priming those cells for inducing a type 1 immune response. The present invention also provides dendritic cell populations useful for activating and for preparing T cells polarized towards production of type 1 cytokines and/or a type 1 response. Similarly, activated, polarized T cell populations, and methods of making the same are provided.

Inventors:

Marnix El. Bosch

Application Number:

JP2015040165A

Publication Date:

April 12, 2017

Filing Date:

March 02, 2015

Export Citation:

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Assignee:

Northwest Biotherapeutics, Incorporated

International Classes:

C12N5/0784; A61K35/26; A61K45/00; A61P37/02; A61P37/04; C12N5/00; C12N5/02; C12N15/09; G06K19/00; C12N

Domestic Patent References:

JP2000143534A

Other References:

International Immunopharmacology,Aug.2001,Vol.1,p.1559-1569
Infection and Immunity,2000,Vol.68,No.12,p.6883-6890
Journal of Immunology,2000,Vol.164,p.4507-4512
Journal of Virology,Apr.2001,Vol.75,No.8,p.3501-3508
Blood,1997,Vol.90,No.5,p.1920-1926
Immunology and Cell Biology,2000,Vol.78,p.318-324
J.Immunol.,Vol.164,No.9(2000)p.4507-4512
Infect.Immun.,Vol.69,No.4(2001.Apr.)p.2456-2461
Immunology,Vol.97,No.4(1999)p.626-633

Attorney, Agent or Firm:

Hidesaku Yamamoto
Natsuki Morishita

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