Title:
A constituent and a method for the medical treatment of an autoimmune disease
Document Type and Number:
Japanese Patent JP6211513
Kind Code:
B2
Abstract:
The invention provides methods and compositions for treating various autoimmune diseases (such as systemic lupus erythematousu) with an interferon inhibitor (such as an anti-intereron-alpha monoclonal antibody). More specifically, the invention provides a method of diagnosing, monitoring and adjusting the treatment of such a patient by way of an interferon signature metric (interferon response gene measurement value), a certain anti-dsDNA antibody titre or being ENA- (levels of extractable nuclear antigens lower than a healthy level). Furthermore, the invention provides articles of manufacture associated with such a diagnosis.
Inventors:
Morimoto, Alyssa, M.
McBride, Jack Lean
Boa menu, richard
Drapa, Jorn
Matthewka, Romeo
Kennedy, William, Dee.
Townsend, Michael, J.
McBride, Jack Lean
Boa menu, richard
Drapa, Jorn
Matthewka, Romeo
Kennedy, William, Dee.
Townsend, Michael, J.
Application Number:
JP2014508569A
Publication Date:
October 11, 2017
Filing Date:
April 26, 2012
Export Citation:
Assignee:
Genentech, Incorporated
International Classes:
A61K39/395; A61K45/00; A61P29/00; A61P37/02; C12Q1/68; G01N33/564
Domestic Patent References:
| JP2010527917A | ||||
| JP2008529529A | ||||
| JP2009534053A |
Foreign References:
| WO2011028933A1 |
Other References:
Arthritis Res Ther.,2010年,12 Suppl 1:S6,1-7
BMC Med.,2010年,8:77,1-5
Clin Exp Immunol.,2010年,159(3),281-91
BMC Med.,2010年,8:77,1-5
Clin Exp Immunol.,2010年,159(3),281-91
Attorney, Agent or Firm:
Sonoda Yoshitaka
Kobayashi Yoshinori
Kobayashi Yoshinori