Title:
腫瘍抗原を直接認識するために組換えＴ細胞レセプターを使用するための組成物及び方法
Document Type and Number:
Japanese Patent JP6612963
Kind Code:
B2
Abstract:
Provided are compositions and methods for prophylaxis and/or therapy of a variety of cancers which express a NY-ESO-1 antigen. Included are recombinant T cell receptors (TCRs), polynucleotides encoding them, expression vectors that include the polynucleotides, and cells into which the polynucleotides have been introduced to produce modified cells, including CD4+ T cells, CD8+ T cells, natural killer T cells, ³´ T cells, and progenitor cells, such as haematopoietic stem cells. The modified cells are capable of direct recognition of a cancer cell expressing a NY-ESO-1 antigen by human leukocyte antigen (HLA) class II-restricted binding of the TCR to the NY-ESO-1 antigen expressed by the cancer cell without presentation of the antigen by antigen presenting cells. In embodiments, the NY-ESO-1 antigen is displayed by the tumor cells. Also included is a method for prophylaxis and/or therapy of cancer by administering modified cells that express a recombinant TCR. Methods for making expression vectors and/or cells which express a recombinant TCR and identifying TCRs to make the expression vectors are also included.
Inventors:
Odungsi, Kunle
Junko Matsuzaki
Takemasa Tsuji
Junko Matsuzaki
Takemasa Tsuji
Application Number:
JP2018244112A
Publication Date:
November 27, 2019
Filing Date:
December 27, 2018
Export Citation:
Assignee:
HEALTH RESEARCH, INC.
International Classes:
C12N5/10; A61K35/28; A61K48/00; A61P35/00; C12N5/0789
Domestic Patent References:
| JP2003520606A | ||||
| JP2009544328A | ||||
| JP2009506753A | ||||
| JP11503014A |
Foreign References:
| WO2012038055A1 | ||||
| WO2007131092A2 |
Other References:
J. Immunother., 2006, Vol.29, No.4, p.398-406
J. Immunol., 2008. Vol.180, No.9, p.6116-6131
Int. J. Cancer, 2009, Vol.125, p.649-655
J. Immunol., 2008. Vol.180, No.9, p.6116-6131
Int. J. Cancer, 2009, Vol.125, p.649-655
Attorney, Agent or Firm:
Patent Business Corporation Minori Patent Office