The constituent for prevention/preventive treatment of poison ivy dermatitis

Japanese Patent JP5934305

B2

The present invention, in one or more embodiments, comprises water-soluble derivatives of 3-n-pentadecylcatechol (poison ivy urushiol saturated congener) and/or 3-n-heptadecylcatechol (poison oak urushiol saturated congener) as compositions for the prevention and/or prophylactic treatment of contact dermatitis caused by poison ivy and poison oak. The present invention is also directed towards processes for making such compounds. Disclosed are compounds which are effective for tolerizing and desensitizing a subject against allergens contained in plants of the Anacardiaceae and Ginkgoaceae families comprising water soluble urushiol esters of general formula (I) tolerizing and desensitizing mammals, including humans, to allergens contained in plants of the Anacardiaceae and Ginkgoaceae families is attained by administering a composition containing at least one water soluble urushiol ester compound.

Elsory Mahmoud A
Gluwa seam
Ashfak Mohamed Khalid
Manly Susan Pee

JP2014158648A

June 15, 2016

August 04, 2014

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The University of Mississippi

C07C225/22; A61K31/222; A61P17/00; A61P37/00

Journal of Pharmaceutical Sciences,1983年,Vol.72, No.7,p.792-795
The Journal of Organic Chemistry,1959年,Vol.24,p.980-985
Immunopharmacology and Immunotoxicology,1995年,Vol.17, No.3,p.565-576
Journal of Investigative Dermatology,1983年,Vol.80, No.3,p.149-155
Journal of Pharmaceutical Science,1981年,Vol.70, No.7,p.829-830

Koichi Tsujii
Sadao Kumakura
Atsushi Hakoda
Kenji Asai
Kazuo Yamazaki
Satsuki Ichikawa
Kobayashi Machiko

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