A covalent bond type Dia body and its use

Japanese Patent JP5964300

B2

Diabody molecules and uses thereof in the treatment of a variety of diseases and disorders, including immunological disorders, infectious disease, intoxication and cancers are disclosed. The diabody molecules comprise two polypeptide chains that associate to form at least two epitope binding sites, which may recognize the same or different epitopes on the same or differing antigens. Additionally, the antigens may be from the same or different molecules. The individual polypeptide chains of the diabody molecule may be covalently bound through non-peptide bond covalent bonds, such as disulfide bonding of cysteine residues located within each polypeptide chain. The diabody molecules may further comprise an Fc region, which allows antibody-like functionality to be engineered into the molecule.

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Johnson Leslie S.
Juan Lin
Rainy Godfrey Jonah Anderson

JP2013523230A

August 03, 2016

July 29, 2011

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Macrogenics, Incorporated

C07K14/315; A61K39/395; A61P35/00; A61P35/02; A61P37/02; C07K16/18; C07K16/28; C07K16/30; C07K19/00; C12N15/09; C12P21/08

JP2007531788A

US20100174053

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Biochemistry,2003年,vol.42,pp.1754-1763
Trends in Biotechnology,2010年 7月,vol.28,pp.355-362

Takaaki Nagashima
Shunsuke Wakayama

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