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Title:
A creatine analog and its use
Document Type and Number:
Japanese Patent JP2016536372
Kind Code:
A
Abstract:
本発明は、任意のクレアチン欠乏症を治療するために有用な新規クレアチン類似体、並びに本発明の化合物及びその医薬組成物もしくは製剤を利用してクレアチン欠乏症を治療及び予防する方法を提供する。一定の実施形態では、新規なクレアチン類似体の親油性を、それらの生物学的利用能を向上させることを目的として、増大させることを探求する。

Inventors:
Jungle Stephen
Chang Yumo
Kakkusu Emir
Application Number:
JP2016553225A
Publication Date:
November 24, 2016
Filing Date:
November 05, 2014
Export Citation:
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Assignee:
ULTRAGENYX PHARMACEUTICAL INC.
International Classes:
C07C279/14; A61K31/223; A61K31/27; A61K31/375; A61K31/685; A61K31/7024; A61K31/7076; A61P9/10; A61P21/00; A61P25/00; A61P43/00; C07C279/22; C07C279/24; C07C323/59; C07D273/08; C07D307/62; C07F9/09; C07H13/04; C07H13/12; C07H19/167
Domestic Patent References:
JP2005528424A2005-09-22
JP2004508407A2004-03-18
JP2015526428A2015-09-10
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Other References:
GARBATI, PATRIZIA ET AL.: "A new method to synthesize creatine derivatives", AMINO ACIDS, vol. 45(4), JPN6018025697, 2013, pages 821-833.
BUROV, SERGEY ET AL.: "Creatinyl amino acids-new hybrid compounds with neuroprotective activity", JOURNAL OF PEPTIDE SCIENCE, vol. 17(9), JPN6018025698, 2011, pages 620-626.
TROTIER-FAURION, ALEXANDRA ET AL.: "Synthesis and Biological Evaluation of New Creatine Fatty Esters Revealed Dodecyl Creatine Ester as", JOURNAL OF MEDICINAL CHEMISTRY, vol. 56(12), JPN6018025699, 2013, pages 5173-5181.
FONS, C. ET AL.: "Response to creatine analogs in fibroblasts and patients with creatine transporter deficiency", MOLECULAR GENETICS AND METABOLISM, vol. 99(3), JPN6018025700, 2010, pages 296-299.
ADRIANO, E. ET AL.: "Searching for a therapy of creatine transporter deficiency: some effects of creatine ethyl ester in", NEUROSCIENCE (AMSTERDAM, NETHERLANDS), vol. 199, JPN6018025701, 2011, pages 386-393.
SIMISTER, PHILIP C. ET AL.: "Novel inhibitors of a Grb2 SH3C domain interaction identified by a virtual screen", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 21(14), JPN6018025702, 2013, pages 4027-4033.
RU 2354645 C1, JPN7018002296
Attorney, Agent or Firm:
Hiroki Masaki
Seiji Ozawa
Yusaku Tokai
Kazuhiro Matsuda
Horiuchi Makoto
Masako Yamauchi
Shuichi Sonomoto
Akihiro Yamamura