A crystal form and a manufacturing method for the same of a Oxazinan compound

Title:

A crystal form and a manufacturing method for the same of a Oxazinan compound

Document Type and Number:

Japanese Patent JP5907310

Kind Code:

B2

Abstract:

Provided are: a crystal form of (-)-(2-{[3-(5-fluoropyridin-2-yl)-1H-pyrazol-1-yl]methyl}-1,3-oxazinan-3-yl)[5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone, said crystal form being stable in the environment of usage thereof as a medicine; and a method for preparing the same. The present invention is crystals of (-)-(2-{[3-(5-fluoropyridin-2-yl)-1H-pyrazol-1-yl]methyl}-1,3-oxazinan-3-yl)[5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone which have at least one of characteristics (a) to (c): (a) in powder X-ray diffraction (Cu-Kα), peaks appear at 2θ=11.1º, 12.5º, 20.3º and 24.2º; (b) the melting point is 124 to 129 ºC; and (c) in the infrared absorption spectrum, characteristic absorption bands appear at 1627cm-1, 1504 cm-1, 1226 cm-1, 1076 cm-1, 822 cm-1 and 783 cm-1. The present invention is also a method for preparing the crystals which is characterized by comprising: dissolving (-)-(2-{[3- (5-fluoropyridin-2-yl)-1H-pyrazol-1-yl]methyl}-1,3-oxazinan-3-yl)[5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone in a mixed solvent consisting of water and either a lower alcohol or acetone; and subjecting the solution to crystallization and then drying.

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Inventors:

Nimura Aya
Noritaka Hattori
Urabe Hiroki
Ogata Yuya
Naoto Osaki

Application Number:

JP2015512427A

Publication Date:

April 26, 2016

Filing Date:

December 09, 2014

Export Citation:

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Assignee:

Taisho Pharmaceutical Co., Ltd.

International Classes:

C07D413/14

Domestic Patent References:

JP2015131803A	2015-07-23
JP2005501026A	2005-01-13
JP2004533440A	2004-11-04
JP2004534026A	2004-11-11
JP2012506376A	2012-03-15

Foreign References:

WO2013187467A1	2013-12-19
WO2013068935A1	2013-05-16

Attorney, Agent or Firm:

Shinjiro Ono
Yasushi Kobayashi
Shigeo Takeuchi
Osamu Yamamoto
Go Kajita

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