Title:
A cure for inflammation and an eye disease relevant to blood vessel multiplication
Document Type and Number:
Japanese Patent JP5942131
Kind Code:
B2
Abstract:
Methods for treating eye diseases associated with inflammation and / or vascular proliferation in subjects are disclosed. The methods include administering therapeutically effective amounts of a tranilast compound, in particular (E)-2-[[3-(3-Methoxy-4-propargyloxy)phenyl)-1-oxo-2-propenyl]amino]benzoic acid or (E)-2-[[3,4-Bis(difluoromethoxy)phenyl)-1-oxo-2-propenyl]amino]benzoic acid or pharmaceutically acceptable salts or solvates thereof.
Inventors:
Kelly, Darren James
Stapleton, David
Stapleton, David
Application Number:
JP2013540174A
Publication Date:
June 29, 2016
Filing Date:
November 10, 2011
Export Citation:
Assignee:
Oculus Lux Proprietary Limited
International Classes:
A61K31/196; A61P27/02; A61P29/00; A61P31/04; A61P31/12; A61P33/00; A61P33/04
Domestic Patent References:
| JP10259129A | ||||
| JP10330254A | ||||
| JP9176003A | ||||
| JP9278653A | ||||
| JP2009541363A |
Foreign References:
| US20070254055 | ||||
| US20090042987 | ||||
| WO1997029744A1 | ||||
| WO1998035668A1 | ||||
| WO2009079692A1 | ||||
| WO2008131481A1 |
Other References:
Haruhisa Ogita et al.,Synthesis and Structuire-Activity Relationship of Diaryamide Derivatives as Selective Inhibitors of the Proliferation of Human Coronary Artery Smooth Muscle Cells,Bioorganic & Medicinal Chemistry Letters,2000年12月 8日,Vol.11,549-551
Steven C. Zammit et al.,Evaluation and optimization of antifibrotic activity of cinnamoyl anthranilates,Bioorganic & Medicinal Chemistry Letters,2009年10月 7日,Vol.19,7003-7006
Steven C. Zammit et al.,Evaluation and optimization of antifibrotic activity of cinnamoyl anthranilates,Bioorganic & Medicinal Chemistry Letters,2009年10月 7日,Vol.19,7003-7006
Attorney, Agent or Firm:
Seiji Ohno
Reiko Tanaka
Yuko Matsuniya
Ken Kitano
Natsuki Ito
Umeda Shinsuke
Reiko Tanaka
Yuko Matsuniya
Ken Kitano
Natsuki Ito
Umeda Shinsuke