Title:
17β-シアノ-18a-ホモ-19-ノル-アンドロスト-4-エン誘導体、その使用及び該誘導体を含む医薬
Document Type and Number:
Japanese Patent JP2010529152
Kind Code:
A
Abstract:
The 17beta-cyano-18a-homo-19-nor-androst-4-ene derivatives of the present invention possess gestagenic activity. They have the general chemical formula 1, in which Z is selected from the group comprising O, two hydrogen atoms, NOR and NNHSO2R, in which R is hydrogen or C1-C4-alkyl, R4 is hydrogen or halogen, furthermore either: R6a, R6b together form methylene or 1,2-ethanediyl or R6a is hydrogen and R6b is selected from the group comprising hydrogen, methyl and hydroxymethylene, and R7 is selected from the group comprising hydrogen, C1-C4-alkyl, C2-C3-alkenyl and cyclopropyl, or: R6a is hydrogen and R6b and R7 either together form methylene or are omitted with formation of a double bond between C6 and C7, R9, R10 are hydrogen or are omitted with formation of a double bond between C9 and C10, R15, R16 are hydrogen or together form methylene, R17 is selected from the group comprising hydrogen, C1-C4-alkyl and allyl, at least one of the substituents R4, R6a, R6b, R7, R15, R16 and R17 not being hydrogen or R6b and R7 being omitted with formation of a double bond between C6 and C7 or being omitted with formation of a double bond between C1 and C2, and moreover comprise their solvates, hydrates, stereoisomers, diastereomers, enantiomers and salts.
Inventors:
Kuhnke, Joachim
Hubner, Yang
Ballman, Rolf
Frenzel, Thomas
Clar, Ulrich
Frederik Menges
Link, sufen
Bolden, Steffen
Moon, Hans-Peter
Prairie, katoya
Hubner, Yang
Ballman, Rolf
Frenzel, Thomas
Clar, Ulrich
Frederik Menges
Link, sufen
Bolden, Steffen
Moon, Hans-Peter
Prairie, katoya
Application Number:
JP2010511525A
Publication Date:
August 26, 2010
Filing Date:
June 04, 2008
Export Citation:
Assignee:
Bayer Schering Pharma Aktiengesellschaft
International Classes:
C07J41/00; A61K31/56; A61K45/00; A61P5/30; A61P5/34; A61P5/42; A61P15/18; A61P43/00; C07J53/00
Domestic Patent References:
| JPS5647200B1 | 1981-11-07 |
Foreign References:
| US3705179A | 1972-12-05 | |||
| US3043833A | 1962-07-10 | |||
| EP0785211A1 | 1997-07-23 | |||
| US3400136A | 1968-09-03 | |||
| US3463776A | 1969-08-26 |
Other References:
JPN6013013419; ＷＩＬＫＳ，Ｊ．Ｍ． ｅｔ ａｌ．: 'Ｓｔｅｒｏｉｄ ｂｉｎｄｉｎｇ ｓｐｅｃｉｆｉｃｉｔｙ ｏｆ ｔｈｅ ｈａｍｓｔｅｒ ｕｔｅｒｉｎｅ ｐｒｏｇｅｓｔｅｒｏｎｅ ｒｅｃｅｐｔｏｒ' ＳＴＥＲＯＩＤＳ Ｖｏｌ．３５， Ｎｏ．６, 1980, ｐ．６９７-７０６
JPN6013013420; ＤＥ ＧＯＯＹＥＲ，Ｍ．Ｅ． ｅｔ ａｌ．: 'Ｒｅｃｅｐｔｏｒ ｐｒｏｆｉｌｉｎｇ ａｎｄ ｅｎｄｏｃｒｉｎｅ ｉｎｔｅｒａｃｔｉｏｎｓ ｏｆ ｔｉｂｏｌｏｎｅ' ＳＴＥＲＯＩＤＳ Ｖｏｌ．６８， Ｎｏ．１, 2003, ｐ．２１-３０
JPN6013013421; ＤＯＲＥ，Ｊ．Ｃ． ｅｔ ａｌ．: 'Ｃｏｒｒｅｓｐｏｎｄａｎｃｅ Ａｎａｌｙｓｉｓ Ａｐｐｌｉｅｄ ｔｏ Ｓｔｅｒｏｉｄ Ｒｅｃｅｐｔｏｒ Ｂｉｎｄｉｎｇ' Ｊ． Ｍｅｄ． Ｃｈｅｍ． Ｖｏｌ．２９， Ｎｏ．１, 1986, ｐ．５４-６０
JPN6013013422; ＳＡＬＭＡＮ，Ｍ． ｅｔ ａｌ．: 'Ａ ＰＯＴＥＮＴＩＡＬ ＲＡＤＩＯＩＯＤＩＮＡＴＥＤ ＬＩＧＡＮＤ ＦＯＲ ＡＮＤＲＯＧＥＮ ＲＥＣＥＰＴＯＲ ７-ＡＬＰＨＡ ＭＥＴＨＹＬ-１７-ＡＬＰＨＡ-２'-Ｅ-ＩＯＤＯＶＩＮＹＬ-１９-ＮＯ' Ｊ． Ｍｅｄ． Ｃｈｅｍ． Ｖｏｌ．３４， Ｎｏ．３, 1991, ｐ．１０１９-２４
JPN6013013420; ＤＥ ＧＯＯＹＥＲ，Ｍ．Ｅ． ｅｔ ａｌ．: 'Ｒｅｃｅｐｔｏｒ ｐｒｏｆｉｌｉｎｇ ａｎｄ ｅｎｄｏｃｒｉｎｅ ｉｎｔｅｒａｃｔｉｏｎｓ ｏｆ ｔｉｂｏｌｏｎｅ' ＳＴＥＲＯＩＤＳ Ｖｏｌ．６８， Ｎｏ．１, 2003, ｐ．２１-３０
JPN6013013421; ＤＯＲＥ，Ｊ．Ｃ． ｅｔ ａｌ．: 'Ｃｏｒｒｅｓｐｏｎｄａｎｃｅ Ａｎａｌｙｓｉｓ Ａｐｐｌｉｅｄ ｔｏ Ｓｔｅｒｏｉｄ Ｒｅｃｅｐｔｏｒ Ｂｉｎｄｉｎｇ' Ｊ． Ｍｅｄ． Ｃｈｅｍ． Ｖｏｌ．２９， Ｎｏ．１, 1986, ｐ．５４-６０
JPN6013013422; ＳＡＬＭＡＮ，Ｍ． ｅｔ ａｌ．: 'Ａ ＰＯＴＥＮＴＩＡＬ ＲＡＤＩＯＩＯＤＩＮＡＴＥＤ ＬＩＧＡＮＤ ＦＯＲ ＡＮＤＲＯＧＥＮ ＲＥＣＥＰＴＯＲ ７-ＡＬＰＨＡ ＭＥＴＨＹＬ-１７-ＡＬＰＨＡ-２'-Ｅ-ＩＯＤＯＶＩＮＹＬ-１９-ＮＯ' Ｊ． Ｍｅｄ． Ｃｈｅｍ． Ｖｏｌ．３４， Ｎｏ．３, 1991, ｐ．１０１９-２４
Attorney, Agent or Firm:
Atsushi Aoki
Takashi Ishida
Fukumoto product
Tetsuji Koga
Kazuhiro Nakamura
Yoichi Watanabe
Kazumi Nakamura
Takashi Ishida
Fukumoto product
Tetsuji Koga
Kazuhiro Nakamura
Yoichi Watanabe
Kazumi Nakamura
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