Title:
17β-シアノ-19-アンドロスト-4-エン誘導体、その使用、及び前記誘導体を含んで成る薬剤
Document Type and Number:
Japanese Patent JP2010529174
Kind Code:
A
Abstract:
The 17β-cyano-19-androst-4-ene derivatives of the present invention possess gestagenic activity. They have the general chemical formula 1, in which Z is selected from the group comprising O, two hydrogen atoms, NOR and NNHSO2R, in which R is hydrogen or C1-C4-alkyl, R1, R2 are each independently hydrogen or methyl, or R1 and R2 together form methylene or are omitted with formation of a double bond between C1 and C2, R4 is hydrogen or halogen, furthermore either: R6a, R6b together form methylene or 1,2-ethanediyl or R6a is hydrogen and R6b is selected from the group comprising hydrogen, methyl and hydroxymethylene, and R7 is selected from the group comprising hydrogen, C1-C4-alkyl, C2-C3-alkenyl and cyclopropyl, or: R6a hydrogen and R6b and R7 together form methylene or are omitted with formation of a double bond between C6 and C7 or: R6a is methyl and R6b and R7 are omitted with formation of a double bond between C6 and C7, R15, R16 are hydrogen or together form methylene, R17 is selected from the group comprising hydrogen, C1-C4-alkyl and allyl, and moreover comprise their solvates, hydrates, stereoisomers, diastereomers, enantiomers and salts, with the proviso that particular compounds are excluded.
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Inventors:
Kuhnke, Joachim
Hubner, Yang
Ballman, Rolf
Frenzel, Thomas
Clar, Ulrich
Frederik Menges
Link, sufen
Bolden, Steffen
Moon, Hans-Peter
Prairie, katoya
Hubner, Yang
Ballman, Rolf
Frenzel, Thomas
Clar, Ulrich
Frederik Menges
Link, sufen
Bolden, Steffen
Moon, Hans-Peter
Prairie, katoya
Application Number:
JP2010511650A
Publication Date:
August 26, 2010
Filing Date:
June 12, 2008
Export Citation:
Assignee:
Bayer Schering Pharma Aktiengesellschaft
International Classes:
C07J3/00; A61K31/56; A61K31/565; A61K31/567; A61K31/569; A61K45/00; A61P15/08; C07J53/00
Domestic Patent References:
| JPS5647200B1 | 1981-11-07 | |||
| JPS60502100A | 1985-12-05 | |||
| JP2005523927A | 2005-08-11 | |||
| JPS5647200B1 | 1981-11-07 | |||
| JPS60502100A | 1985-12-05 | |||
| JP2005523927A | 2005-08-11 |
Foreign References:
| US3705179A | 1972-12-05 | |||
| US3463776A | 1969-08-26 | |||
| WO2006061309A1 | 2006-06-15 | |||
| US3480711A | 1969-11-25 | |||
| GB1563843B | ||||
| US3463776A | 1969-08-26 | |||
| WO2006061309A1 | 2006-06-15 | |||
| US3480711A | 1969-11-25 | |||
| GB1563843B |
Other References:
JPN6013013411; ＯＬＤＥＮＺＩＥＬ，Ｏ．Ｈ． ｅｔ ａｌ: 'Ｃｈｅｍｉｓｔｒｙ ｏｆ ｓｕｌｆｏｎｙｌｍｅｔｈｙｌ ｉｓｏｃｙａｎｉｄｅｓ． １３． Ａ ｇｅｎｅｒａｌ ｏｎｅ-ｓｔｅｐ ｓｙｎｔｈｅｓｉｓ ｏｆ ｎｉｔｒｉｌｅｓ ｆｒｏｍ ｋｅｔｏｎｅｓ' Ｊｏｕｒｎａｌ ｏｆ Ｏｒｇａｎｉｃ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．４２， Ｎｏ．１９, 1977, ｐ．３１１４-８
JPN6013013410; ＳＡＬＭＡＮ，Ｍ． ｅｔ ａｌ．: Ｊ． Ｍｅｄ． Ｃｈｅｍ． Ｖｏｌ．３４， Ｎｏ．３, 1991, ｐ．１０１９-２４
JPN6013013411; ＯＬＤＥＮＺＩＥＬ，Ｏ．Ｈ． ｅｔ ａｌ: 'Ｃｈｅｍｉｓｔｒｙ ｏｆ ｓｕｌｆｏｎｙｌｍｅｔｈｙｌ ｉｓｏｃｙａｎｉｄｅｓ． １３． Ａ ｇｅｎｅｒａｌ ｏｎｅ-ｓｔｅｐ ｓｙｎｔｈｅｓｉｓ ｏｆ ｎｉｔｒｉｌｅｓ ｆｒｏｍ ｋｅｔｏｎｅｓ' Ｊｏｕｒｎａｌ ｏｆ Ｏｒｇａｎｉｃ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．４２， Ｎｏ．１９, 1977, ｐ．３１１４-８
JPN6013013410; ＳＡＬＭＡＮ，Ｍ． ｅｔ ａｌ．: Ｊ． Ｍｅｄ． Ｃｈｅｍ． Ｖｏｌ．３４， Ｎｏ．３, 1991, ｐ．１０１９-２４
JPN6013013410; ＳＡＬＭＡＮ，Ｍ． ｅｔ ａｌ．: Ｊ． Ｍｅｄ． Ｃｈｅｍ． Ｖｏｌ．３４， Ｎｏ．３, 1991, ｐ．１０１９-２４
JPN6013013411; ＯＬＤＥＮＺＩＥＬ，Ｏ．Ｈ． ｅｔ ａｌ: 'Ｃｈｅｍｉｓｔｒｙ ｏｆ ｓｕｌｆｏｎｙｌｍｅｔｈｙｌ ｉｓｏｃｙａｎｉｄｅｓ． １３． Ａ ｇｅｎｅｒａｌ ｏｎｅ-ｓｔｅｐ ｓｙｎｔｈｅｓｉｓ ｏｆ ｎｉｔｒｉｌｅｓ ｆｒｏｍ ｋｅｔｏｎｅｓ' Ｊｏｕｒｎａｌ ｏｆ Ｏｒｇａｎｉｃ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．４２， Ｎｏ．１９, 1977, ｐ．３１１４-８
JPN6013013410; ＳＡＬＭＡＮ，Ｍ． ｅｔ ａｌ．: Ｊ． Ｍｅｄ． Ｃｈｅｍ． Ｖｏｌ．３４， Ｎｏ．３, 1991, ｐ．１０１９-２４
Attorney, Agent or Firm:
Atsushi Aoki
Takashi Ishida
Fukumoto product
Tetsuji Koga
Kazuhiro Nakamura
Yoichi Watanabe
Masaru Nakajima
Takashi Ishida
Fukumoto product
Tetsuji Koga
Kazuhiro Nakamura
Yoichi Watanabe
Masaru Nakajima