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Title:
ジキレート化剤としてのポリアザシクロアルカン
Document Type and Number:
Japanese Patent JP3541951
Kind Code:
B2
Abstract:
This invention relates to dichelants, in particular compounds having two macrocyclic chelant groups linked by a bridge containing an ester or amide bond, especially compounds of formula (V) (wherein each X which may be the same or different is NZ, O or S, at least two Xs being NZ; each Z is a group R<1> or a group CR<1>2Y, at least one Z, and preferably 2 or 3 Zs, on each macrocyclic ring being a group CR<1>2Y; each Y is a group CO2H, PO3H, SO3H, CONR<1>2, CON(OR<1>)R<1>, CNS or CONR<1>NR<1>2, preferably COOH; m is 0 or 1 or 2, preferably 1; each n is 2 or 3, preferably 2; q is 1 or 2, preferably 1; each R<1> which may be the same or different is a hydrogen atom or an alkyl group optionally substituted by one or more hydroxy and/or alkoxy groups; and D is a bridging group, other than an unsubstituted carbonylaminoethylaminocarbonyl group, having a molecular weight of less than 1000, preferably less than 500, joining two macrocyclic rings via at least one amide or ester bond) and salts and metal chelates thereof.

Inventors:
Carvalho, Joan
Ferman, Jere, Douglas
Watson, Alan, David
Koo, Michael
Application Number:
JP51067195A
Publication Date:
July 14, 2004
Filing Date:
September 29, 1994
Export Citation:
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Assignee:
Nicomed Salter, INC.
International Classes:
G01R33/28; A61B5/055; A61K31/395; A61K31/495; A61K49/00; A61K49/06; A61K51/00; A61N5/00; A61P39/00; A61P39/02; A61P43/00; C07D255/02; C07D257/02; C07D273/00; C07D285/00; C07D401/14; C07D403/06; C07D403/14; C07D405/14; C07D409/14; C07F5/00; C07F9/547; C07F9/6524; C07H23/00; C09K3/00; (IPC1-7): C07D257/02; A61B5/055; A61K31/395; A61K31/495; A61N5/00; A61P39/00; A61P43/00; C07D403/06; C09K3/00; G01R33/28
Domestic Patent References:
JP5504125A
JP63041468A
JP4288063A
Attorney, Agent or Firm:
Shunichiro Suzuki