Title:
A cytokine removal method from blood using polysaccharide which carried out surface fixation
Document Type and Number:
Japanese Patent JP6072189
Kind Code:
B2
Abstract:
The present invention is directed to a method for removing cytokines and/or pathogens from blood or blood serum (blood) by contacting the blood with a solid, essentially non microporous substrate which has been surface treated with heparin, heparan sulfate and/or other molecules or chemical groups (the adsorbent media or media) having a binding affinity for the cytokine or pathogen(s) to be removed (the adsorbates), and wherein the size of the interstitial channels within said media is balanced with the amount of media surface area and the surface concentration of binding sites on the media in order to provide adequate adsorptive capacity while also allowing relatively high flow rates of blood through the adsorbent media.
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Inventors:
Ward, robert es
McClear, Keith Earl
Larum, me
Adolfson, Lars
McClear, Keith Earl
Larum, me
Adolfson, Lars
Application Number:
JP2015201863A
Publication Date:
February 01, 2017
Filing Date:
October 13, 2015
Export Citation:
Assignee:
Xterra Medical Corporation
International Classes:
A61M1/36; A61K35/14; A61P1/04; A61P17/02; A61P31/04
Domestic Patent References:
| JP2009521413A |
Foreign References:
| WO2002060512A1 | ||||
| WO2000038763A1 |
Attorney, Agent or Firm:
Shinjiro Ono
Yasushi Kobayashi
Shigeo Takeuchi
Osamu Yamamoto
Akiko Yamaguchi
Yasushi Kobayashi
Shigeo Takeuchi
Osamu Yamamoto
Akiko Yamaguchi
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