Title:
【発明の名称】Δ9,11および21-クロロコルチコステロイドの調製方法
Document Type and Number:
Japanese Patent JPH09506113
Kind Code:
A
Abstract:
Described is a process for the regioselective dehydration of 11-hydroxy steroids using PCl5, PCl3, POCl3 or either SO2Cl2 and imidazole, or PPh3 and CCl4. The disclosed process selectively forms DELTA <9,11> steroids from either 11- alpha - or 11- beta -hydroxy steroids, and can also be used for the one-step conversion of 11,21-dihydroxy steroids to 21-chloro- DELTA <9,11> steroids. Also disclosed are processes for the regioselective conversion of 11- beta -chloro steroids to DELTA <9,11> steroids, and for regioselectively converting an 11,17,21-trihydroxy steroid to a 21-chloro-11,17-dihydroxy steroid.
Inventors:
Fu, Jao Young
Chilvenga Dam, Chilvetipram Kay.
Tan, butterfly-han
Lee, Junning
Cologne, caesar
Chilvenga Dam, Chilvetipram Kay.
Tan, butterfly-han
Lee, Junning
Cologne, caesar
Application Number:
JP50102196A
Publication Date:
June 17, 1997
Filing Date:
May 30, 1995
Export Citation:
Assignee:
Schering Corporation
International Classes:
C07J5/00; C07J7/00; C07J51/00; C07J; (IPC1-7): C07J5/00; C07J51/00; C07J7/00
Attorney, Agent or Firm:
Shusaku Yamamoto