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Title:
血管内皮細胞増殖因子依存性血管内皮細胞増殖の抑制剤
Document Type and Number:
Japanese Patent JP4633223
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To obtain the subject inhibitor capable of exhibiting antagonistic activities or the like against the bond of a vascular endothelial cell growth factor(VEGF) to heparan sulfate or heparin present in the vascular endothelial cell by including a sulfated glucosaminopglycan containing a large amount of N-sulfate group and 6-sulfate group. SOLUTION: This inhibitor contains a sulfated glycosaminoglycan having repeating structure of a disaccharide unit composed of glucosamine and hexuronic acid, as a base skeleton, and its salt. The sulfated glycosaminoglycan and the salt have a composition containing >=40 mol% ΔDiHS-di(6,N)S of the formula (R1 and R2 are each SO3-; R3 is H) measured by a disaccharide composition analysis combining the degradation by a glycosaminoglycan-splitting enzyme with a high-pressure liquid chromatography, and the salt thereof. The daily dose of the sulfated glycosaminoglycan is exemplified by 100 μg/kg to 100 mg/kg as a clinical dose.

Inventors:
Masayuki Ishihara
Katsuaki Ono
Yoshiyoshi Suzuki
Application Number:
JP2000099433A
Publication Date:
February 16, 2011
Filing Date:
March 31, 2000
Export Citation:
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Assignee:
Seikagaku Corporation
International Classes:
A61K31/727; C12Q1/02; A61K31/737; A61P27/02; A61P35/00; A61P43/00; C08B37/00; C08B37/10; C12R1/91
Domestic Patent References:
JP63278901A
JP6506685A
JP11035603A
JP10218902A
JP2001151680A
JP2001187740A
JP2000344674A
JP2002003384A
JP2002020293A
JP63119500A
Foreign References:
WO1996006867A1
Other References:
Jaseja, M. et al.,"Novel regio- and stereoselective modifications of heparin in alkaline solution. Nuclear magnetic resonance spectroscopic evidence",Canadian Journal of Chemistry,1989年,Vol.67, No.9,p.1449-1456
Casu, B. et al.,"Retention of Antilipemic Activity by Periodate-oxidized Non-anticoagulant Heparins",Arzneimittel-Forschung / Drug Reserch,1986年,Vol.36(I), No.4,p.637-642
Ashikari, S. et al.,"Characterization of Heparan Sulfate Oligosaccharides That Bind to Hepatocyte Growth Factor",The Journal of Biological Chemistry,1995年12月 8日,Vol.270, No.49,p.29586-29593
Attorney, Agent or Firm:
Shisei Patent Office
Hajime Hasegawa
Sumiko Matsuda
Kumi Kondo