Title:
アルツハイマー病の治療のためのテルフェニル誘導体
Document Type and Number:
Japanese Patent JP5422827
Kind Code:
B2
Abstract:
The present invention relates to compounds having the general formula (I) with the definitions of X, Y, R 1 -R 4 given below, and/or a salt or ester thereof.
Furthermore the invention relates to the use of said compounds for the treatment of Alzheimer's disease and their use for the modulation of ³-secretase activity.
Inventors:
Wilson Francis
Jones allison
Leader valery
Harrison Richard John
Miyu Sunase
Hernades-Pani Remedios
Major Jeremy
Bussar Cyril
Bell kathrin
Taylor jess
Morel aderin
Cansfield Andrew
Burghart Svenya
Chang Yang
Hochin Yun
Jones allison
Leader valery
Harrison Richard John
Miyu Sunase
Hernades-Pani Remedios
Major Jeremy
Bussar Cyril
Bell kathrin
Taylor jess
Morel aderin
Cansfield Andrew
Burghart Svenya
Chang Yang
Hochin Yun
Application Number:
JP2009506772A
Publication Date:
February 19, 2014
Filing Date:
April 19, 2007
Export Citation:
Assignee:
Jansen Pharmaceuticals, Inc.
Cellsome Limited
Cellsome Limited
International Classes:
C07C57/58; A61K31/192; A61K31/216; A61K31/41; A61P25/28; A61P43/00; C07C51/09; C07C57/60; C07C59/56; C07C59/64; C07C227/18; C07C229/40; C07C253/30; C07C255/57; C07C315/04; C07C317/44; C07B51/00; C07B57/00; C07B61/00
Domestic Patent References:
| JP2009504705A | ||||
| JP2003531194A | ||||
| JP2001504139A | ||||
| JP8325182A | ||||
| JP2005534620A | ||||
| JP2004530254A |
Foreign References:
| WO2004052921A1 | ||||
| WO2006008558A1 | ||||
| WO2005110963A1 | ||||
| WO2004096220A1 |
Other References:
ZIMMERMANN,T. and FISCHER,G.W.,Pyrylium compounds. 36. Substituted benzoic acid esters from 2,4,6-triarylpyrylium salts and α-ketocarboxylic acid esters,Journal fuer Praktische Chemie(Leipzig),1987年,Vol.329, No.3,p.499-510
Attorney, Agent or Firm:
Hatsushi Shimizu
Toshi Gobe
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Ryuichi Inoue
Masato Ozeki
Toshi Gobe
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Ryuichi Inoue
Masato Ozeki